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Drug resistance during chemotherapy is the major obstacle to the successful treatment of many cancers. Here, we report that inhibition of NF-E2-related factor 2 (Nrf2) may be a promising strategy to combat chemoresistance. Nrf2 is a critical transcription factor regulating a cellular protective response that defends cells against toxic insults from a broad(More)
In response to oxidative stress, Nrf2 and p21(Cip1/WAF1) are both upregulated to protect cells from oxidative damage. Nrf2 is constantly ubiquitinated by a Keap1 dimer that interacts with a weak-binding (29)DLG motif and a strong-binding (79)ETGE motif in Nrf2, resulting in degradation of Nrf2. Modification of the redox-sensitive cysteine residues on Keap1(More)
A genomic database consists of a set of nucleotide sequences , for which an important kind of queries is the local sequence alignment. This paper investigates two different indexing techniques, namely the variations of GNAT trees [1] and M-trees [3], to support fast query evaluation for local alignment, by transforming the alignment problem to a variant(More)
beta-Thalassemia and sickle cell disease both display a great deal of phenotypic heterogeneity, despite being generally thought of as simple Mendelian diseases. The reasons for this are not well understood, although the level of fetal hemoglobin (HbF) is one well characterized ameliorating factor in both of these conditions. To better understand the genetic(More)
In object-oriented programming languages, multiple dispatching provides increased expressive power over single dispatching by guiding method look-up using the values of all arguments instead of the receiver only. There have been several programming languages supporting this mechanism and they demonstrate its usefulness. However, efficient implementation of(More)
Arsenic is widely spread in our living environment and imposes a big challenge on human health worldwide. Arsenic damages biological systems through multiple mechanisms including the generation of reactive oxygen species. The transcription factor Nrf2 regulates the cellular antioxidant response that protects cells from various insults. In this study, the(More)