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Drug resistance during chemotherapy is the major obstacle to the successful treatment of many cancers. Here, we report that inhibition of NF-E2-related factor 2 (Nrf2) may be a promising strategy to combat chemoresistance. Nrf2 is a critical transcription factor regulating a cellular protective response that defends cells against toxic insults from a broad(More)
beta-Thalassemia and sickle cell disease both display a great deal of phenotypic heterogeneity, despite being generally thought of as simple Mendelian diseases. The reasons for this are not well understood, although the level of fetal hemoglobin (HbF) is one well characterized ameliorating factor in both of these conditions. To better understand the genetic(More)
A genomic database consists of a set of nucleotide sequences , for which an important kind of queries is the local sequence alignment. This paper investigates two different indexing techniques, namely the variations of GNAT trees [1] and M-trees [3], to support fast query evaluation for local alignment, by transforming the alignment problem to a variant(More)
We present a novel technique for multiple-dispatching. In object-oriented programming languages, multiple-dispatching provides increased expressive power over single-dispatching by guiding method lookup using the values of all arguments instead of the receiver only. However, the efficient implementation for multiple-dispatching is still critical with regard(More)
In response to oxidative stress, Nrf2 and p21(Cip1/WAF1) are both upregulated to protect cells from oxidative damage. Nrf2 is constantly ubiquitinated by a Keap1 dimer that interacts with a weak-binding (29)DLG motif and a strong-binding (79)ETGE motif in Nrf2, resulting in degradation of Nrf2. Modification of the redox-sensitive cysteine residues on Keap1(More)
The transcription factor Nrf2 has emerged as a master regulator of the endogenous antioxidant response, which is critical in defending cells against environmental insults and in maintaining intracellular redox balance. However, whether Nrf2 has any role in neuronal cell differentiation is largely unknown. In this report, we have examined the effects of Nrf2(More)