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Collective Cell Motility Promotes Chemotactic Prowess and Resistance to Chemorepulsion
Collective cell migration is a widespread biological phenomenon, whereby groups of highly coordinated, adherent cells move in a polarized fashion. This migration mode is a hallmark of tissueExpand
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Cortical forces and CDC-42 control clustering of PAR proteins for Caenorhabditis elegans embryonic polarization
Cell polarization enables zygotes to acquire spatial asymmetry, which in turn patterns cellular and tissue axes during development. Local modification in the actomyosin cytoskeleton mediates spatialExpand
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Screening therapeutic EMT blocking agents in a three-dimensional microenvironment.
Epithelial-mesenchymal transition (EMT) plays a critical role in the early stages of dissemination of carcinoma leading to metastatic tumors, which are responsible for over 90% of all cancer-relatedExpand
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Loss of α-catenin elicits a cholestatic response and impairs liver regeneration
The liver is unique in its capacity to regenerate after injury, during which hepatocytes actively divide and establish cell-cell contacts through cell adhesion complexes. Here, we demonstrate thatExpand
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Ectodermal Influx and Cell Hypertrophy Provide Early Growth for All Murine Mammary Rudiments, and Are Differentially Regulated among Them by Gli3
Mammary gland development starts in utero with one or several pairs of mammary rudiments (MRs) budding from the surface ectodermal component of the mammalian embryonic skin. Mice develop five pairs,Expand
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Positive and Negative Regulation of Gli Activity by Kif7 in the Zebrafish Embryo
Loss of function mutations of Kif7, the vertebrate orthologue of the Drosophila Hh pathway component Costal2, cause defects in the limbs and neural tubes of mice, attributable to ectopic expressionExpand
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Cortical forces and CDC-42 control clustering of PAR proteins for C. elegans embryonic polarization
membrane potential. drp1 mutant PFCs also showed increased Ras and phosphorylated ERK and loss of Notch mediated differentiation. In order to dissect out the distinct roles of metabolism andExpand
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Endocytic reawakening of motility in jammed epithelia
Dynamics of epithelial monolayers has recently been interpreted in terms of a jamming or rigidity transition. How cells control such phase transitions is, however, unknown. Here we show that RAB5A, aExpand
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Nuclear import of a lipid-modified transcription factor
Lipid-modified transcription factors (TFs) are biomolecular oddities since their reduced mobility and membrane attachment appear to contradict nuclear import required for their gene-regulatoryExpand
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Steering cell migration by alternating blebs and actin-rich protrusions
BackgroundHigh directional persistence is often assumed to enhance the efficiency of chemotactic migration. Yet, cells in vivo usually display meandering trajectories with relatively low directionalExpand
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