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The receptor-interacting serine-threonine kinase 3 (RIP3) is a key signaling molecule in the programmed necrosis (necroptosis) pathway. This pathway plays important roles in a variety of physiological and pathological conditions, including development, tissue damage response, and antiviral immunity. Here, we report the identification of a small molecule(More)
BACKGROUND The dysregulation of oncogenes and tumor suppressor genes plays an important role in many cancers, including hepatocellular carcinoma (HCC), which is one of the most common cancers in the world. In a previous microarray experiment, we found that DLGAP5 is overexpressed in HCCs. However, whether the up-regulation of DLGAP5 contributes to(More)
Molecular markers are defined as the fragments of DNA sequence associated with a genome, which areused to identify a particular DNA sequence. Nowadays, with the explosive growth of genetic research and bacterial classification, molecular marker is an important tool to identify bacterial species. Taking account to its significant roles in clinic, medicine(More)
Differences in 5-hydroxymethylcytosine, 5hmC, distributions may complicate previous observations of abnormal cytosine methylation statuses that are used for the identification of new tumor suppressor gene candidates that are relevant to human hepatocarcinogenesis. The simultaneous detection of 5-methylcytosine and 5-hydroxymethylcytosine is likely to(More)
The identification of potential oncogenes plays an important role in finding novel therapeutic targets for many cancers, including hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. In our previous research, using microarray technology, we found that FAM83D was overexpressed in HCCs. However, whether the overexpression of(More)
The use of chemoprotective agents to minimize the side effects of the chemotherapy, primarily via activation of the Nrf2 pathway, is an emerging research field, which has attracted broad attention from both academia and pharmaceutical industry. Through high-throughput chemical screens we have disclosed that pterisolic acid B (J19), a naturally occuring(More)
JoggAR demonstrates a novel combination of wearable visual, audio and sensing technology to realize a game-like persistent augmented reality (AR) environment to enhance jogging and other exertion experiences that involves changing attention intensities in the course of the activities. In particular we developed a method to perform an <i>audio-first(More)
To increase network users' satisfaction and continuous behavior, e-commerce platform is concentrated on providing users more enjoyment during consuming online. Online personalized system can help e-commerce platform know more users' preference, which aims to increase degree of match between service, product and preference, need, but users pay attention to(More)
Ag2O-decorated flower-like ZnO composites were fabricated through a chemical precipitation process. X-ray diffraction analysis confirms the co-existence of cubic Ag2O and wurtzite ZnO phases. Scanning electron microscopy images reveal Ag2O nanoparticles located on the rough surface of ZnO flowers. The photocatalytic activities of the composites with various(More)
The Raman spectra of all-trans-lycopene in n-hexane were measured under high pressure, and the results compared with those of β-carotene. The different pressure effects on Raman spectra are analyzed taking into account the different structures of lycopene and β-carotene molecules. It is concluded that: (a) the vibronic coupling between the S₁ and S₀ states(More)