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Optimum coherent receivers for CPM-signals have in general a high degree of complexity. Especially for the most interesting schemes that offer significant power and bandwidth efficiency with smoothed frequency pulses, o r that implement a n additional convolu-tional code, the number of parallel filters at the receiver input, and the number of memory-states(More)
Acquisition of cell identity in plants relies strongly on positional information, hence cell-cell communication and inductive signalling are instrumental for developmental patterning. During Arabidopsis embryogenesis, an extra-embryonic cell is specified to become the founder cell of the primary root meristem, hypophysis, in response to signals from(More)
Tightly controlled gene expression is a hallmark of multicellular development and is accomplished by transcription factors (TFs) and microRNAs (miRNAs). Although many studies have focused on identifying downstream targets of these molecules, less is known about the factors that regulate their differential expression. We used data from high spatial(More)
Abshnct-By means of a signal representation in a signal space spanned by a few time-limited exponential basis-functions, and data-aided maximum-liltelhood techniques, novel methods for the joint and nosioint estimation of carrier-phase and symbol-W i g for general coherent CPM receivers am! pmposed. The estimators are quite simple, especially in obtaining(More)
The sodium-vitamin C co-transporter SVCT2 is primarily responsible for the accumulation of the important antioxidant ascorbate into brain cells. In vitro studies have demonstrated strong expression of this transporter in cultured astrocytes, whereas in situ hybridization analysis has so far detected SVCT2 only in neurons. In the present study, we examined(More)
The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in vivo. Antagomir-365, an anti-miR-365(More)
Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation. Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance when stressed by a high-fat diet, suggesting a potential role in nutrient homeostasis. Here we show that(More)
Tumor control of hepatocellular carcinoma by radiotherapy remains unsatisfactory. The phosphatidylinositol 3-kinase (PI3K)/Akt pathway plays a critical role in inhibiting cancer cell death. Elevated PI3K/Akt activity is associated with increased cellular resistance to irradiation. Our aim was to determine whether the inhibition of PI3K/Akt activity by a(More)
Reactive gliosis caused by post-traumatic injury often results in marked expression of chondroitin sulfate proteoglycan (CSPG), which inhibits neurite outgrowth and regeneration. Methylprednisolone (MP), a synthetic glucocorticoid, has been shown to have neuroprotective and anti-inflammatory effects for the treatment of acute spinal cord injury (SCI).(More)
As the Glass-Steagall restrictions on bank underwriting were relaxed in the U.S. during the 1990s, the Financial System Reform Act of 1993 in Japan allowed commercial banks to underwrite securities. We examine the controversy that universal banking creates conflicts of interest. We find that upon entry into securities business, banks excessively discount(More)