Weili Chen

2Carlos Duarte-Guevara
2Tanmay Ghonge
2Brian T Cunningham
1Sheng Zhang
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We demonstrate photonic crystal enhanced fluorescence (PCEF) microscopy as a surface-specific fluorescence imaging technique to study the adhesion of live cells by visualizing variations in cell-substrate gap distance. This approach utilizes a photonic crystal surface incorporated into a standard microscope slide as the substrate for cell adhesion, and a(More)
OBJECTIVE Leptomeningeal collaterals, which affects tissue fate, are still challenging to assess. Four-dimensional CT angiography (4D CTA) originated from CT perfusion (CTP) provides the possibility of non-invasive and time-resolved assessment of leptomeningeal collateral flow. We sought to develop a comprehensive rating system to integrate the speed and(More)
BACKGROUND HMS5552, a novel fourth-generation glucokinase (GK) activator, has demonstrated promising effects on glycemic control in preclinical models of type 2 diabetes. This single ascending dose study was conducted to investigate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of HMS5552 during its first-in-human exposure. (More)
Viral load measurements are an essential tool for the long-term clinical care of hum an immunodeficiency virus (HIV)-positive individuals. The gol d standards in viral load instrumentation, however, are still too limited by their size, cost, and sophisticated operation for these measurements to be ubiquitous in remote settings with poor healthcare(More)
Medical Instrumentation—Article 1 Schematic of inverted pyramidal microwell structure lysis buffer, RT-LAMP was performed in the thermocycler with identical mastermixes containing reaction buffers, enzymes , and primers, but where the sample portion consisted of various ratios by volume of whole blood to lysis buffer: 1: 4, 1: 2, 1:1, or 1: 0. Viruses were(More)
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