Weikai Li

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  • Weikai Li, Sol Schulman, Rachel J Dutton, Dana Boyd, Jon Beckwith, Tom A Rapoport
  • 2010
Vitamin K epoxide reductase (VKOR) generates vitamin K hydroquinone to sustain gamma-carboxylation of many blood coagulation factors. Here, we report the 3.6 A crystal structure of a bacterial homologue of VKOR from Synechococcus sp. The structure shows VKOR in complex with its naturally fused redox partner, a thioredoxin-like domain, and corresponds to an(More)
Many secretory proteins are targeted by signal sequences to a protein-conducting channel, formed by prokaryotic SecY or eukaryotic Sec61 complexes, and are translocated across the membrane during their synthesis. Crystal structures of the inactive channel show that the SecY subunit of the heterotrimeric complex consists of two halves that form an(More)
The recent surge in popularity of crowdsourcing has brought with it a new opportunity for engaging human intelligence in the process of data analysis. Crowdsourcing provides a fundamental mechanism for enabling online workers to participate in tasks that are either too difficult to be solved solely by a computer or too expensive to employ experts to(More)
Mobile augmented reality (MAR) has exploded in popularity on mobile devices in various fields. However, building a MAR application from scratch on mobile devices is complicated and time-consuming. In this paper, we propose CloudRidAR, a framework for MAR developers to facilitate the development, deployment, and maintenance of MAR applications with little(More)
The application of molecular replacement (MR) in macromolecular crystallography can be limited by the "model bias" problem. Here we propose a strategy to reduce model bias when only part of a new structure is known: after the MR search, structure determination of the unknown part of the new structure can be facilitated by cross-crystal averaging of the(More)
The intramembrane vitamin K epoxide reductase (VKOR) supports blood coagulation in humans and is the target of the anticoagulant warfarin. VKOR and its homologues generate disulphide bonds in organisms ranging from bacteria to humans. Here, to better understand the mechanism of VKOR catalysis, we report two crystal structures of a bacterial VKOR captured in(More)
We present Ubii (Ubiquitous interface and interaction), an interface system that aims to expand people's perception and interaction from the digital space to the physical world. The centralized user interface is broken into pieces woven in the domain environment. Augmented user interface is paired to the physical objects, where physical and digital(More)
Numerical dissipation acts as artificial viscosity to make smoke viscous. Reducing numerical dissipation is able to recover visual details smeared out by the numerical dissipation. Great efforts have been devoted to suppress the numerical dissipation in smoke simulation in the past few years. In this paper we investigate methods of combating the numerical(More)
  • Weikai Li, Sol Schulman, Rachel J. Dutton, Dana Boyd, Jon Beckwith, Tom A. Rapoport
  • 2010
Figure S1 | Chemical structures relevant to the vitamin K cycle. a, Vitamin K cycle involving -glutamyl carboxylase (GGCX) and vitamin K epoxide reductase (VKOR). Gla, -carboxylated Glu residues. b, Structure of the VKOR inhibitor warfarin and of ubiquinone. VKORs from representative organisms were aligned by the CLUSTAL W2 algorithm 32 and manually(More)
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