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Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.

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Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria.

TLDR
An efficient approach for exploring the anticancer mechanism of oridonin through development of the potent fluorescent analogues is reported, which confirmed that cytochrome c played an important role in oridonIn induced mitochondrion-mediated apoptosis and α,β-unsaturated ketone is the active moiety oforidonin, which is crucial to its uptake, localization, and cytotoxicity.
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On the structure of the bioactive constituent from ayurvedic medicine Salacia reticulata: revision of the literature

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Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.

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A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway.

TLDR
The most potent compound, 13p, was 200-fold more efficacious than oridonin in MCF-7 cancer cells and induced apoptosis and cell cycle arrest at the G2/M phase, suggesting that the mitochondrial pathway was involved in the 13p-mediated apoptosis.
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Regioselective C2 Oxidative Olefination of Indoles and Pyrroles through Cationic Rhodium(III)-Catalyzed C-H Bond Activation.

TLDR
An efficient Rh-catalyzed oxidative olefination of indoles and pyrroles with broad substrate scope and tolerance is reported and the catalytic reaction proceeds with excellent regio- and stereoselectivity.
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Ruthenium-catalyzed regioselective C2 alkenylation of indoles and pyrroles via C-H bond functionalization.

An efficient ruthenium-catalyzed oxidative coupling of indoles and pyrroles with various alkenes at the C2-position assisted by employing the N,N-dimethylcarbamoyl moiety as a directing group is…
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Regioselective ortho olefination of aryl sulfonamide via rhodium-catalyzed direct C-H bond activation.

TLDR
Rh(III)-catalyzed ortho C-H olefination of aryl sulfonamide directed by the SO2NHAc group is reported, achieving highly efficiently and selectively with a broad substrate scope.
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Discovery of novel antitumor nitric oxide-donating β-elemene hybrids through inhibiting the PI3K/Akt pathway.

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Another mode of heterocyclization of an enantiopure C2-symmetric bis-epoxide leading to the symmetric dialkyl sulfide

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