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- Publications
- Influence
Long noncoding and circular RNAs in lung cancer: advances and perspectives.
- Weijia Xie, S. Yuan, Z. Sun, Y. Li
- Biology, Medicine
- Epigenomics
- 2 September 2016
Better understanding and management of lung cancer are needed. Although much has been learned from known protein coding genes, long noncoding RNAs (lncRNAs), a relatively new and fast evolving large… Expand
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.
- Weijia Xie, G. Tanabe, +6 authors O. Muraoka
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 March 2011
Two hitherto missing members of sulfonium salts family in Salacia genus plants as a new class of α-glucosidase inhibitors, neoponkoranol (7) and neosalaprinol (8), were isolated from the water… Expand
Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes
- H. Yaghootkar, C. Lamina, +73 authors T. Frayling
- Biology, Medicine
- Diabetes
- 17 September 2013
Adiponectin is strongly inversely associated with insulin resistance and type 2 diabetes, but its causal role remains controversial. We used a Mendelian randomization approach to test the hypothesis… Expand
Genetic Variants Associated With Glycine Metabolism and Their Role in Insulin Sensitivity and Type 2 Diabetes
- Weijia Xie, A. Wood, +20 authors Mark Walker
- Biology, Medicine
- Diabetes
- 17 May 2013
Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain. We previously identified novel… Expand
Circulating exosomal microRNAs as prognostic biomarkers for non-small-cell lung cancer
Exosomal miRNAs are proposed as excellent candidate biomarkers for clinical applications. However, little is known about their potential roles as prognostic biomarkers in lung cancer. In this study,… Expand
Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria.
- S. Xu, Shanshan Luo, +9 authors Jinyi Xu
- Chemistry, Medicine
- Journal of medicinal chemistry
- 27 April 2016
Oridonin (1) is a complex ent-kaurane diterpenoid exhibiting remarkable antitumor activity. However, the detailed mechanism or cellular target that underlies this activity has not yet been… Expand
On the structure of the bioactive constituent from ayurvedic medicine Salacia reticulata: revision of the literature
- O. Muraoka, Weijia Xie, G. Tanabe, Mumen F. A. Amer, T. Minematsu, M. Yoshikawa
- Chemistry
- 15 December 2008
The reported structure of a potent α-glucosidase inhibitor 7 isolated recently from ayurvedic medicine Salacia reticulata was found incorrect, and the compound was proved to be de-O-sulfated… Expand
Hypoxia‐sensitive LINC01436 is regulated by E2F6 and acts as an oncogene by targeting miR‐30a‐3p in non‐small cell lung cancer
Dysregulation of long noncoding RNA (lncRNA) is known to be involved in numerous human diseases, including lung cancer. However, the precise biological functions of most lncRNA remain to be… Expand
Long non-coding RNA MUC5B-AS1 promotes metastasis through mutually regulating MUC5B expression in lung adenocarcinoma
Long non-coding RNAs (lncRNAs) have been involved in the process of cancer occurrence, progression, and treatment. Lung cancer-related lncRNAs are still an emerging field, thus we sought to identify… Expand
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.
- Weijia Xie, G. Tanabe, +5 authors O. Muraoka
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 April 2011
Synthesis and evaluation of four diastereomers (9a, 9b, 9c and 9d) of kotalanol, a potent α-glucosidase inhibitor isolated from an Ayurvedic medicinal plant Salacia species, are described.… Expand