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Autophagy plays a vital role in cerebral ischemia and may be a potential target for developing novel therapy for stroke. In this study, we constructed an autophagy-related pathway network by analyzing the genes related to autophagy and ischemic stroke, and the risk genes were screened. Two autophagy-related modules were significantly up-regulated and(More)
PURPOSE To evaluate the efficacy and safety of a dual femoral-popliteal approach in the supine position after failed antegrade recanalization attempts in chronic total occlusion (CTO) of the superficial femoral artery (SFA). MATERIALS AND METHODS From May 2011 to October 2012, 21 patients underwent dual femoral-popliteal recanalization for CTO of the SFA,(More)
OBJECTIVE The migration and proliferation of vascular smooth muscle cells (VSMC) are early and crucial events in the pathogenesis of intimal hyperplasia, the primary cause of restenosis after vascular reconstruction. We tested the hypothesis that down-regulation of Rab5a, a prototypical member of the Rab family of GTPases, leads to inhibition ofVSMC(More)
Long non-coding RNAs (IncRNAs) play important roles in various biological processes, such as transcriptional regulation, cell growth and tumorigenesis. However, little is known about the role of IncRNA HIF 1 alpha-antisense RNA 1 (HIF1a-AS1) in regulating the proliferation and apoptosis of vascular smooth muscle cells (VSMCs) and the expression of HIF1a-AS1(More)
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