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BACKGROUND The most widely used multiple sequence alignment methods require sequences to be clustered as an initial step. Most sequence clustering methods require a full distance matrix to be computed between all pairs of sequences. This requires memory and time proportional to N2 for N sequences. When N grows larger than 10,000 or so, this becomes(More)
Mitra is a scalable storage manager that supports the display of continuous media data types, e.g., audio and video clips. It is a software based system that employs oo-the-shelf hardware components. Its present hardware platform is a cluster of multi-disk workstations, connected using an ATM switch. Mitra supports the display of a mix of media types. To(More)
In a scalable server that supports the retrieval and display of continuous media (audio and video clips), both the number of simultaneous displays and the expected startup latency of a display increases as a function of additional disk bandwidth. Based on a striping technique and a round-robin placement of data, this paper describes object replication and(More)
This paper describes a buffer sharing technique that strikes a balance between the use of disk bandwidth and memory in order to maximize the performance of a video-on-demand server. We make the key observation that the configuration parameters of the system should be independent of the physical characteristics of the data (e.g., popularity of a clip).(More)
BACKGROUND Explicit evolutionary models are required in maximum-likelihood and Bayesian inference, the two methods that are overwhelmingly used in phylogenetic studies of DNA sequence data. Appropriate selection of nucleotide substitution models is important because the use of incorrect models can mislead phylogenetic inference. To better understand the(More)
BACKGROUND A well-informed choice of genetic locus is central to the efficacy of DNA barcoding. Current DNA barcoding in animals involves the use of the 5' half of the mitochondrial cytochrome oxidase 1 gene (CO1) to diagnose and delimit species. However, there is no compelling a priori reason for the exclusive focus on this region, and it has been shown(More)
BACKGROUND More and more nucleotide sequences of type A influenza virus are available in public databases. Although these sequences have been the focus of many molecular epidemiological and phylogenetic analyses, most studies only deal with a few representative sequences. In this paper, we present a complete analysis of all Haemagglutinin (HA) and(More)
The outbreak of highly pathogenic avian influenza (HPAI) H5N1 disease has led to significant loss of poultry and wild life and case fatality rates in humans of 60%. Wild birds are natural hosts for all avian influenza virus subtypes and over120 bird species have been reported with evidence of H5N1 infection. Influenza A viruses possess a segmented RNA(More)
BACKGROUND Since its emergence in March 2009, the pandemic 2009 H1N1 influenza A virus has posed a serious threat to public health. To trace the evolutionary path of these new pathogens, we performed a selection-pressure analysis of a large number of hemagglutinin (HA) and neuraminidase (NA) gene sequences of H1N1 influenza viruses from different hosts. (More)
KEYWORDS We consider a VOD architecture depicted in Figure 1. The Video-on-demand; data sharing: cost-effectiveness; system configuration. ABSTRACT In a Video-on-Demand server, requests from different clients are independent of each other and may arrive at random time. Commercial systems may contain hundreds to thousands of clients and thus providing an(More)