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BACKGROUND On March 30, 2013, a novel avian influenza A H7N9 virus that infects human beings was identified. This virus had been detected in six provinces and municipal cities in China as of April 18, 2013. We correlated genomic sequences from avian influenza viruses with ecological information and did phylogenetic and coalescent analyses to extrapolate the(More)
BACKGROUND Since its emergence in March 2009, the pandemic 2009 H1N1 influenza A virus has posed a serious threat to public health. To trace the evolutionary path of these new pathogens, we performed a selection-pressure analysis of a large number of hemagglutinin (HA) and neuraminidase (NA) gene sequences of H1N1 influenza viruses from different hosts. (More)
BACKGROUND The most widely used multiple sequence alignment methods require sequences to be clustered as an initial step. Most sequence clustering methods require a full distance matrix to be computed between all pairs of sequences. This requires memory and time proportional to N2 for N sequences. When N grows larger than 10,000 or so, this becomes(More)
UNLABELLED The Middle East respiratory syndrome coronavirus (MERS-CoV) causes a severe acute respiratory tract infection with a high fatality rate in humans. Coronaviruses are capable of infecting multiple species and can evolve rapidly through recombination events. Here, we report the complete genomic sequence analysis of a MERS-CoV strain imported to(More)
Mitra is a scalable storage manager that supports the display of continuous media data types, e.g., audio and video clips. It is a software based system that employs oo-the-shelf hardware components. Its present hardware platform is a cluster of multi-disk workstations, connected using an ATM switch. Mitra supports the display of a mix of media types. To(More)
Since February 2013, infections with several novel avian-origin influenza viruses have occurred in Taiwan and the Mainland of China. The H7N9 influenza virus has caused 136 human infections with 44 deaths in the first influenza season, and has continued to cause infections during the current influenza season (Li et al., 2014). As of February 11th, 2014, a(More)
BACKGROUND Explicit evolutionary models are required in maximum-likelihood and Bayesian inference, the two methods that are overwhelmingly used in phylogenetic studies of DNA sequence data. Appropriate selection of nucleotide substitution models is important because the use of incorrect models can mislead phylogenetic inference. To better understand the(More)
In a scalable server that supports the retrieval and display of continuous media (audio and video clips), both the number of simultaneous displays and the expected startup latency of a display increases as a function of additional disk bandwidth. Based on a striping technique and a round-robin placement of data, this paper describes object replication and(More)