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Excessive lipid accumulation in macrophages plays an important role in the development of atherosclerosis. Recently, several studies have implied that resistin, an adipocytokine which is mainly expressed in human peripheral blood monocytes, may take part in the pathogenesis of atherosclerosis. In this study, we investigated the effects of resistin on lipid(More)
Obesity is associated with increased risk of developing numerous adverse health conditions. Cathepsin k (CTSK) is highly expressed in adipose tissues of obese patients and animal models. Although CTSK has been demonstrated to promote adipocyte differentiation in 3T3-L1 cells, the effects of CTSK selective inhibitor (CKSI) on weight gain and insulin(More)
We present a new and effective algorithm, balanced k-means, for partitioning areas in large-scale vehicle routing problem (VRP). The algorithm divides two-stage procedures. The traditional k-means is used to partition the whole customers into several areas in the first stage and a border adjustment algorithm aims to adjust the unbalanced areas to be(More)
This purpose was to discuss optimal reference value for normal glucose tolerance (NGT) at different time points during an oral glucose tolerance test (OGTT) by receiver operating characteristic (ROC) analysis. One thousand seven hundred and forty-six subjects from March 2004 to March 2005 were given 75 g OGTT and the blood samples were collected at 0, 30,(More)
We present a new neighbor search algorithm named route-nearest neighbor (RNN) for searching the next node in large-scale vehicle routing problem (VRP). The RNN algorithm is used to divide the area customers into several routes. The key step in the route construction is how to search the next node (i.e., neighbor). Different from the Nearest Neighbor (NN)(More)
In our previous work, a thrombin-like enzyme (TLE), agkihpin, was successfully isolated, purified, cloned and named from the venom of Gloydius halys Pallas, having fibrinolytic, fibrinogenolytic and thrombosis-reduced activities, attenuating migration of liver cancer cell, and without bleeding risk. To explore the possibility of agkihpin as a thrombolytic(More)
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