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BACKGROUND MicroRNA-223 (miR-223) is a hematopoietic lineage cell-specific microRNA. However, a significant amount of miR-223 has been identified in vascular smooth muscle cells (VSMCs) and vascular walls that should not have endogenous miR-223. OBJECTIVES This study sought to determine the sources of miR-223 in normal and atherosclerotic arteries and the(More)
We demonstrate the fabrication of highly open spherical cages with large through pores using high aspect ratio cellulose nanocrystals with "haystack" shell morphology. In contrast to traditional ultrathin shell polymer microcapsules with random porous morphology and pore sizes below 10 nm with limited molecular permeability of individual macromolecules, the(More)
This paper suggests an approximate algorithm to solve general 0-1 integer programming problems. This algorithm belongs to the class of lexicographic enumeration algorithms. Theoretical analysis and a strict mathematical proof of convergence property of the algorithm are presented , as well as experimental investigation to engineering structural optimization(More)
Cancer-associated fibroblasts (CAFs) are the main component of tumor stroma which support tumor progression. Here, we set out to determine the factors that may be involved in dramatic alteration of microRNAs (miRNAs) expression pattern in CAFs. miRNAs analyses identified differential expression of 15 microRNAs, with miR-101 being the most downregulated(More)
PURPOSE We aimed at assessing the overall efficacy of angiogenesis inhibitor (AI)-containing regimens in the treatment of advanced non-small-cell lung cancer (NSCLC) according to histological types. METHODS Studies from PubMed and Web of Science, and abstracts presented at American Society of Clinical Oncology (ASCO) meeting up to October 31, 2014 were(More)
Sorafenib was the only small-molecule drug approved by FDA for treatment of the advanced hepatocellular carcinoma (HCC). Recent study indicated that YM155 was a promising agent for HCC cells with high survivin expression, however, the antitumor activity needs to be further improved. Based on molecular docking and rational design method, a series of(More)
A moderate heat-resistant lipase gene from Bacillus subtilis FS1403 was cloned. Sequence analysis revealed that the lipase gene encodes a 212-amino-acid protein containing the conserved motif Ala-X-Ser-X-Gly that is present in other Bacillus lipases. Phylogenetic analysis suggested that the B. subtilis FS1403 lipase gene belongs to family I.4 of bacterial(More)
A measurement system of dynamic resistance of vehicle electronic line connector based on PXI Express(PXIe) technology was established. The system hardware was composed of PXIe box, PXIe high speed digitalizer, PXIe arbitrary waveform generator, high precision currency source and so forth. And the system operating interface was designed by LabVIEW, the(More)
Angiotensin receptor blockers (ARBs) are the most commonly used blood pressure-lowering drugs in the world. However, the preventive value of ARBs on lung cancer is still controversial. Therefore, it was necessary for us to perform a meta-analysis to evaluate the value of ARBs on lung cancer risk. We searched the PubMed database as well as the Web of Science(More)
—The successive approximation register analog to digital converter (SAR ADC) technique is not yet mature in China mainly because of the imperfect analog module of the SAR ADC. The purpose of this design was to optimize the analog module by designing and making a 8-bit 1MHz SAR ADC and testing a 12-bit SAR ADC theoretically and by simulation. The design of(More)