Wei-ze Zhang

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OBJECTIVE To explore the effects of valsartan and MEK1/2 inhibitor U0126 on atrial fibrosis and connexin40 (Cx40) remodeling in rats treated with isoproterenol (ISO). METHODS 32 male SD rats were randomly divided into control group (A), ISO (5 mg · kg(-1) · d(-1) for 7 days) + DMSO group (B), ISO + U0126 (0.5 mg · kg(-1) · d(-1) for 28 days) group (C,(More)
OBJECTIVE To explore the effects of glutamine (Gln) induced heat shock protein 70(Hsp70) overexpression on atrial fibrosis and connexin 43 remodeling in isoprenaline(ISO)treated rats and related mechanisms. METHODS Forty male SD rats were randomly divided into five groups (n = 8 each group): control group, DMSO group, ISO 5 mg×kg(-1)×d(-1) group (Fibrosis(More)
Objective To study the effects of simvastatin on the hypertrophy of cultured rat cardiac myocytes induced by serum and the role of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in the signal pathway. Methods Cultured neonatal SpragueDawley (SD) rat cardiac myocytes were treated with 15% fetal bovine serum, or without serum, or different(More)
To the Editor: Concurrence of acute ischemic stroke and acute myocardial infarction (AMI) is rare but serious in clinical scenarios.[1‐3] Reperfusion therapy, with no or minimal delay, is optimized strategy to save both vital organs in such urgency. Here, we report a case of successful salvage with urgent thrombolysis plus carotid angioplasty, followed by(More)
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