Wei-yong Zhu

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Expressed sequence tags (ESTs) from normal and tumor tissues have been deposited in public databases. These ESTs and all mRNA sequences were aligned with the human genome sequence using LEADS, Compugen's alternative splicing modeling platform. We developed a novel computational approach to analyze tissue information of aligned ESTs in order to identify(More)
DC-3F/FA3 (FA3) cells, selected for growth in folic acid-free medium containing dialyzed serum and 15 pM [6S]-folinic acid, and parental DC-3F cells were compared by mRNA differential display to identify genetic changes occurring during selection. One of the genes found to be overexpressed in FA3 cells was metallothionein II (MT-II). Northern blots using a(More)
important roles in the integrin signaling pathway, were identified as the major proteins showing RA-induced tyrosine phosphorylation. The reti-noid X receptor-selective compound SR11237 failed to induce tyrosine phosphorylation, indicating that retinoid X receptor activation is not involved in this phenomenon. In contrast, stable overexpression of a(More)
OBJECTIVE To explore the effects of Candesartan cilexetil on the rats exposed to silica. METHOD Ninety-six wistar rats were randomly divided into model-group, intervention-group and control-group (32 rats a group). The intervention-group, model-group and control group were orally exposed to Candesartan cilexetil (10 mg/kg) and normal solution for a week,(More)
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