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Effect of Vitamin E Administration on the Elevated Oxygen Stress and the Telomeric and Subtelomeric Status in Alzheimer’s Disease
Background: Oxidative stress (OS) may be involved in the neurodegenerative process in Alzheimer’s disease (AD). Telomeres, the repeated sequences that cap chromosome ends, undergo shortening with… Expand
Different levels of hypoxia regulate telomere length and telomerase activity
This study was designed to identify changes in telomere length and telomerase activity in human umbilical vein endothelial cells (HUVECs) exposed to various levels of hypoxia. Mild hypoxia (10%, 15%… Expand
Alteration of telomere length and subtelomeric methylation in human endothelial cell under different levels of hypoxia.
BACKGROUND AND AIMS Hypoxia-associated changes of telomeric structure in cell cultures have been analyzed mainly in cancer cells, stem cells, or cells transduced with vectors containing the… Expand
Patients with multiple sclerosis show increased oxidative stress markers and somatic telomere length shortening
- J. Guan, Wei-ping Guan, T. Maeda, Xie Guo-qing, Wan Guang-zhi, N. Makino
- Biology, Medicine
- Molecular and Cellular Biochemistry
- 1 February 2015
Lipid peroxidation due to oxidative stress (OS) may play an important role in the pathogenesis of chronic systemic inflammatory diseases such as multiple sclerosis (MS). Telomeres, repeated sequences… Expand
The Subtelomere of Short Telomeres is Hypermethylated in Alzheimer's Disease.
Telomere shortening has been reported to be related to oxidative stress (OS) associated with the aging process and aging-associated diseases, including Alzheimer's disease (AD). We measured the… Expand
Vitamin E administration erases an enhanced oxidation in multiple sclerosis.
- J. Guan, Wei-ping Guan, T. Maeda
- Medicine, Chemistry
- Canadian journal of physiology and pharmacology
- 9 August 2018
Systemic peroxidation status has been reported as a pathogenic factor for multiple sclerosis (MS). Systemically elevated oxidation levels are associated with serum lipid peroxidation and somatic… Expand
[Correlation between lacunar cerebral infarction and serum uric acid level in elderly male hypertension patients].
- L. Jiang, L. Cheng, W. Wu, Q. Ma, Wei-ping Guan
- Zhongguo ying yong sheng li xue za zhi = Zhongguo…
- 1 July 2014
OBJECTIVE To study the correlation between lacunar cerebral infarction and level of serum uric acid in elderly male hypertension patients. METHODS Ninety-eight elderly male hypertension patients… Expand
[Neuropsychological features of elderly patients with mild cognitive impairment susceptible to Alzheimer's disease].
- Zhong-bao Gao, W. Wang, Zhen-fu Wang, Wei-ping Guan, Wei-ping Wu
- Zhonghua yi xue za zhi
- 17 January 2012
OBJECTIVE To explore the neuropsychological features of elderly patients with mild cognitive impairment (MCI) susceptible to Alzheimer's disease (AD). METHODS A total of 47 patients with MCI… Expand
f e f rent n lev e els of hy h poxia regulat a e telomere lengt g h and telomerase act c iv i it i y
Estimation of oxidative stress in patients with Parkinson's disease
Objective To measure the changes in urinary 8-iso-prostaglandin-F2α (8-iso-PGF2α) and oxidized low-density lipoprotein (ox-LDL) lag time in patients with Parkinson's disease (PD). Methods A… Expand