Wei-min Chai

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PURPOSE To investigate the brain iron deposits in patients with Alzheimer's disease (AD) and healthy age-matched controls using phase imaging. MATERIALS AND METHODS Twenty-six AD patients and 24 healthy controls were recruited. A three-dimensional high-resolution, gradient-echo sequence was used to acquire phase data in the coronal plane. A high-pass(More)
BACKGROUND/AIMS To compare proton magnetic resonance spectroscopy ((1)H-MRS) and diffusion tensor imaging (DTI) findings in the posterior cingulate regions in patients with Alzheimer's disease (AD). METHODS 17 patients with mild AD, 20 with moderate to severe AD and 20 cognitively normal aging subjects (CN) underwent single-voxel MRS and DTI examinations.(More)
To demonstrate the feasibility of the ultrasmall superparamagnetic iron oxide (USPIO) modified by cyclo (Arg-Gly-Asp-Try-Cys) peptide (c(RGDyC)-USPIO) for targeting hepatic stellate cells (HSCs). A c(RGDyC)-USPIO probe was prepared by conjugating c(RGDyC) with USPIO through a thiol-maleinide interaction. The specificity of c(RGDyC)-USPIO for HSCs was(More)
A community-based survey on the prevalence of knee osteoarthritis (OA) and associated factors was carried out in Shanghai, People’s Republic of China. Of 2,305 registered residents ≥40 years of age, 2,093 were examined by interview and questionnaire. One hundred ninety knee pain-positive and 510 knee pain-negative subjects received radiography. Radiographic(More)
AIM To retrospectively analyze the imaging features of solid-pseudopapillary tumors (SPTs) of the pancreas on multi-detector row computed tomography (MDCT) and define the imaging findings suggestive of malignant potential. METHODS A total of 24 consecutive cases with surgically and pathologically confirmed SPTs of the pancreas underwent preoperative(More)
It is crucial to understand the distribution of embolic agents inside target liver during and after the hepatic portal vein embolization (PVE) procedure. For a long time, the problem has not been well solved due to the radiolucency of embolic agents and the resolution limitation of conventional radiography. In this study, we first reported use of(More)
The purpose of the study was to evaluate the feasibility of microbubbles as phase contrast imaging (PCI) agents for angiography applications. The hypothesis was that the introduction of microbubbles into tissue produces a significant change in the refractive index and highlights the lumen of the vessel in PCI. The absorption and phase contrast images of(More)
The primary goal of this study was to evaluate the feasibility of using anti-vascular endothelial growth factor receptor 2 (VEGFR2)-conjugated poly(lactic-co-glycolic acid) (PLGA) microspheres as an x-ray phase contrast agent to assess the VEGFR2 expression in cell cultures. The cell lines, mouse LLC (Lewis lung carcinoma) and HUVEC (human umbilical vein(More)
The objective of this study was to explore the potential of CO₂ single contrast in-line phase contrast imaging (PCI) for pre-clinical small intestine investigation. The absorption and phase contrast images of CO₂ gas production were attained and compared. A further increase in image contrast was observed in PCI. Compared with CO₂-based absorption contrast(More)
Super-paramagnetic microbeads are widely used for cell isolation. Evaluation of the binding affinity of microbeads to cells using optical microscopy has been limited by its small scope. Here, magnetic property of microbeads was first investigated by using synchrotron radiation (SR) in-line x-ray phase contrast imaging (PCI). The cell line mouse LLC (Lewis(More)