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Structures of Human Golgi-resident Glutaminyl Cyclase and Its Complexes with Inhibitors Reveal a Large Loop Movement upon Inhibitor Binding*
- Kai-Fa Huang, S. Liaw, A. H. Wang
- Biology, ChemistryThe Journal of Biological Chemistry
- 1 February 2011
Comparisons of the inhibitor-bound structures revealed distinct interactions of the inhibitors with gQC and sQC, which are consistent with the results from the inhibitor assays reported here, and suggest the different inhibitor binding modes allow the design of specific inhibitors toward gQ C and s QC.
Crystal structure and functional analysis of the glutaminyl cyclase from Xanthomonas campestris.
Interleukin-18 deteriorates Fabry cardiomyopathy and contributes to the development of left ventricular hypertrophy in Fabry patients with GLA IVS4+919 G>A mutation
IL-18 may be a novel marker for evaluating ERT efficacy, and targeting IL-18 might be a potential adjunctive therapy combined with ERT for the treatment of advanced cardiomyopathy in FC patients with IVS4+919 G>A mutation.
Obesity and pain: a systematic review
- Shao-Hua Chin, Wei-lin Huang, S. Akter, M. Binks
- PsychologyInternational Journal of Obesity
- 17 December 2019
The current systematic review considered research published within the 10 years preceding June 2019, dealing with the topic of obesity and pain, to identify gaps in the literature and to highlight key targets for future transdisciplinary research.
Thyrostimulin-TSHR signaling promotes the proliferation of NIH:OVCAR-3 ovarian cancer cells via trans-regulation of the EGFR pathway
- Wei-lin Huang, Zhongyou Li, Ting-Yu Lin, Sheng-Wen Wang, Fang-Ju Wu, C. Luo
- Biology, MedicineScientific reports
- 7 June 2016
Thyrostimulin-driven TSHR activation is found in both rat normal ovarian surface epithelium and human epithelial ovarian cancers (EOCs) and proved that this ancient glycoprotein hormone system is involved in NIH:OVCAR-3 cell proliferation for the first time, suggesting that it may possibly become a novel oncotarget when studying ovarian cancer.
Induced epigenetic modifications of the promoter chromatin silence survivin and inhibit tumor growth.
Inhibition of Smurf2 translation by miR-322/503 protects from ischemia reperfusion injury by modulating EZH2/Akt/GSK3β signaling.
- Wei Dong, Fei Xie, Xiao-Ping Peng
- Biology, MedicineAmerican journal of physiology. Cell physiology
- 1 August 2019
This study demonstrates that miR-322/503 plays a beneficial role in myocardial I/R injury by inhibiting Smurf2 translation, inducing EZH2 expression and activates Akt/GSK3β pathway, thereby protecting cells from ischemia reperfusion injury.
Identifying a Neuromedin U Receptor 2 Splice Variant and Determining Its Roles in the Regulation of Signaling and Tumorigenesis In Vitro
Results reveal the presence of previously uncharacterized heteromeric relationships among NMU receptors but also provide NMUR2S as a potential therapeutic target for the future treatment of NMU signaling-mediated cancers.
miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway.
- Xuanxin Chen, Wei-lin Huang, Xiao-Ping Peng, Yan-Ni Lv, Jun-he Li, J. Xiong
- BiologyToxicology research
- 5 September 2019
Collectively, miR-140-5p mediated the BVZ-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway, indicating that miR/5p may be a novel target for treating BVz-induced cardiotoxicity.
In vivo selection reveals autophagy promotes adaptation of metastatic ovarian cancer cells to abdominal microenvironment
An in vivo mouse peritoneal dissemination scheme was established that allowed us to select more aggressive sublines from parental ovarian cancer cells, including A2780 and SKOV‐3, and indicated that autophagy‐related genes were enriched in selected malignant sublines.