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Control Flow Integrity (CFI) provides a strong protection against modern control-flow hijacking attacks. However, performance and compatibility issues limit its adoption. We propose a new practical and realistic protection method called CCFIR (Compact Control Flow Integrity and Randomization), which addresses the main barriers to CFI adoption. CCFIR(More)
BACKGROUND Outcomes are poor for patients with previously treated, advanced or metastatic non-small-cell lung cancer (NSCLC). The anti-programmed death ligand 1 (PD-L1) antibody atezolizumab is clinically active against cancer, including NSCLC, especially cancers expressing PD-L1 on tumour cells, tumour-infiltrating immune cells, or both. We assessed(More)
User interface (UI) interactions are essential to Android applications, as many Activities require UI interactions to be triggered. This kind of UI interactions could also help malicious apps to hide their sensitive behaviors (e.g., sending SMS or getting the user's device ID) from being detected by dynamic analysis tools such as TaintDroid, because simply(More)
Fuzz testing has proven successful in finding security vulnerabilities in large programs. However, traditional fuzz testing tools have a well-known common drawback: they are ineffective if most generated malformed inputs are rejected in the early stage of program running, especially when target programs employ checksum mechanisms to verify the integrity of(More)
LH/hCG receptors were disrupted by gene targeting in embryonic stem cells. The disruption resulted in infertility in both sexes. The gonads contained no receptor mRNA or receptor protein. Serum LH levels were greatly elevated, and FSH levels were moderately elevated in both sexes; estradiol and progesterone levels decreased but were not totally suppressed(More)
A quantitative genetic model relates the genotypic value of an individual to the alleles at the loci that contribute to the variation in a population in terms of additive, dominance, and epistatic effects. This partition of genetic effects is related to the partition of genetic variance. A number of models have been proposed to describe this relationship:(More)
An app market’s vetting process is expected to be scalable and effective. However, today’s vetting mechanisms are slow and less capable of catching new threats. In our research, we found that a more powerful solution can be found by exploiting the way Android malware is constructed and disseminated, which is typically through repackaging legitimate apps(More)
The number of identified integer overflow vulnerabilities has been increasing rapidly in recent years. In this paper, we present a system, IntScope, which can automatically detect integer overflow vulnerabilities in x86 binaries before an attacker does, with the goal of finally eliminating the vulnerabilities. IntScope first translates the disassembled code(More)
NOTCH signaling is a key regulator of cell fate decisions in prenatal skeletal development and is active during adult tissue renewal. In addition, its association with neoplasia suggests that it is a candidate therapeutic target. We find that attenuated NOTCH signaling enhances osteoclastogenesis and bone resorption in vitro and in vivo by a combination of(More)
Lipopolysaccharide (LPS) modulates bone resorption by augmentation of osteoclastogenesis. It increases in osteoblasts the production of RANKL, interleukin (IL)-1, prostaglandin E2 (PGE2), and TNF-alpha, each known to induce osteoclast activity, viability, and differentiation. We examined the role of direct interactions of LPS with osteoclast precursors in(More)