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The information rate of finite-state source/channel models can be accurately estimated by sampling both a long channel input sequence and the corresponding channel output sequence, followed by a forward sum-product recursion on the joint source/channel trellis. This method is extended to compute upper and lower bounds on the information rate of very general(More)
A single-base pair resolution silkworm genetic variation map was constructed from 40 domesticated and wild silkworms, each sequenced to approximately threefold coverage, representing 99.88% of the genome. We identified ~16 million single-nucleotide polymorphisms, many indels, and structural variations. We find that the domesticated silkworms are clearly(More)
Lead, as one of the most hazardous heavy metals to the environment interferes with lignocellulosic biomass bioconversion and carbon cycles in nature. The degradation of lead-polluted lignocellulosic waste and the restrain of lead hazards by solid-state fermentation with Phanerochaete chrysosporium were studied. Phanerochaete chrysosporium effectively(More)
—In this paper, an adaptive tradeoff model (ATM) is proposed for constrained evolutionary optimization. In this model, three main issues are considered: 1) the evaluation of infeasible solutions when the population contains only infeasible individuals; 2) balancing feasible and infeasible solutions when the population consists of a combination of feasible(More)
In virtual colonoscopy, CT scans are typically acquired with the patient in both supine (facing up) and prone (facing down) positions. The registration of these two scans is desirable so that the user can clarify situations or confirm polyp findings at a location in one scan with the same location in the other, thereby improving polyp detection rates and(More)
Moving object segmentation in compressed domain plays an important role in many real-time applications, e.g. video indexing, video transcoding, video surveillance, etc. Because H.264/AVC is the up-to-date video-coding standard, few literatures have been reported in the area of video analysis on H.264/AVC compressed video. Compared with the former MPEG(More)
Faulty components in a network need to be localized and repaired to sustain the health of the network. In this paper, we propose a novel approach that carefully combines active and passive measurements to localize faults in wireless sensor networks. More specifically, we formulate a problem of optimal sequential testing guided by end-to-end data. This(More)
BACKGROUND Dipeptidyl peptidase-IV (DPP-IV) inhibitors represent a new class of oral antihyperglycemic agents. Sitagliptin is an orally active and selective DPP-IV inhibitor currently in Phase III development for the treatment of type 2 diabetes mellitus. OBJECTIVE The aim of this study was to assess the pharmacokinetic and pharmacodynamic (PK/PD)(More)
AIMS Sitagliptin is a selective inhibitor of dipeptidyl peptidase-4 (DPP-4) used to treat type 2 diabetes. The present aim was to evaluate pharmacokinetic (PK), pharmacodynamic (PD) and safety characteristics of sitagliptin following single doses in healthy, young Japanese males. METHODS In this alternating two-panel, randomized, controlled double-blind(More)
Epigenetics plays a key role in the pathogenesis of diabetic nephropathy (DN), although the precise regulatory mechanism is still unclear. Here, we examined the role of endoplasmic reticulum (ER) stress in histone H3 lysine 4 (H3K4) methyltransferase SET7/9-induced monocyte chemoattractant protein-1 (MCP-1) expression in the kidneys of db/db mice. Our(More)