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Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer.
PURPOSE Increased hepatocyte growth factor/MET signaling is associated with poor prognosis and acquired resistance to epidermal growth factor receptor (EGFR) -targeted drugs in patients withExpand
Joint Optimization of Relay Strategies and Resource Allocations in Cooperative Cellular Networks
TLDR
This paper considers a wireless cooperative cellular data network with a base station and many subscribers in which the subscribers have the ability to relay information for each other to improve the overall network performance. Expand
Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein
Nudel and Lis1 appear to regulate cytoplasmic dynein in neuronal migration and mitosis through direct interactions. However, whether or not they regulate other functions of dynein remains elusive.Expand
Hydrogen sulfide promotes root organogenesis in Ipomoea batatas, Salix matsudana and Glycine max.
In this report, we demonstrate that sodium hydrosulfide (NaHS), a hydrogen sulfide (H(2)S) donor, promoted adventitious root formation mediated by auxin and nitric oxide (NO). Application of theExpand
Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase.
The microtubule-based motor cytoplasmic dynein/dynactin is a force generator at the kinetochore. It also transports proteins away from kinetochores to spindle poles. Regulation of such diverseExpand
Onartuzumab plus erlotinib versus erlotinib in previously treated stage IIIb or IV NSCLC: Results from the pivotal phase III randomized, multicenter, placebo-controlled METLung (OAM4971g) global
8000 Background: A placebo-controlled, phase II trial of erlotinib + onartuzumab, a humanized monovalent antibody to the MET receptor, demonstrated a benefit in progression-free survival (PFS) when...
A molecular switch for the orientation of epithelial cell polarization.
The formation of epithelial tissues containing lumens requires not only the apical-basolateral polarization of cells, but also the coordinated orientation of this polarity such that the apicalExpand
Covariance Based Joint Activity and Data Detection for Massive Random Access with Massive MIMO
TLDR
This paper makes an observation that in the massive multiple-input multiple-output (MIMO) regime, where the BS is equipped with a large number of antennas, a covariance based detection scheme that solves a maximum likelihood estimation problem is more effective than the approximate message passing (AMP) based compressed sensing approach for sequence detection. Expand
Interrelationship between non-invasive measurements of atherosclerosis: flow-mediated dilation of brachial artery, carotid intima-media thickness and pulse wave velocity.
Flow-mediated dilation (FMD) of the brachial artery, carotid intima-media thickness (IMT) and pulse wave velocity (PWV) have been shown to be good surrogate markers of clinical atherosclerosis. WeExpand
Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structures.
Epithelial cells form monolayers of polarized cells with apical and basolateral surfaces. Madin-Darby canine kidney epithelial cells transiently lose their apico-basolateral polarity and becomeExpand
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