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Birds are the most species-rich class of tetrapod vertebrates and have wide relevance across many research fields. We explored bird macroevolution using full genomes from 48 avian species representing all major extant clades. The avian genome is principally characterized by its constrained size, which predominantly arose because of lineage-specific erosion(More)
As the mobile platform continues to pervade all aspects of human activity, and mobile applications, or mobile apps for short, on this platform tend to be faulty just like other types of software, there is a growing need for automated testing techniques for mobile apps. Model-based testing is a popular and important testing approach that operates on a model(More)
Many ion channel genes have been associated with human genetic pain disorders. Here we report two large Chinese families with autosomal-dominant episodic pain. We performed a genome-wide linkage scan with microsatellite markers after excluding mutations in three known genes (SCN9A, SCN10A, and TRPA1) that cause similar pain syndrome to our findings, and we(More)
A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key factor for hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is also required for HCV entry. Mutational study of CLDN1 revealed that its tight junctional distribution plays an important role in mediating viral entry. Together, these data support(More)
Although eusociality evolved independently within several orders of insects, research into the molecular underpinnings of the transition towards social complexity has been confined primarily to Hymenoptera (for example, ants and bees). Here we sequence the genome and stage-specific transcriptomes of the dampwood termite Zootermopsis nevadensis (Blattodea)(More)
In fungi and metazoans, extracellular signals are often perceived by G-protein-coupled receptors (GPCRs) and transduced through heterotrimeric G-protein complexes to downstream targets. Plant heterotrimeric G proteins are also involved in diverse biological processes, but little is known about their upstream receptors. Moreover, the presence of bona fide(More)
Application markets such as Apple's App Store and Google's Play Store have played an important role in the popularity of smartphones and mobile devices. However, keeping malware out of application markets is an ongoing challenge. While recent work has developed various techniques to determine what applications do, no work has provided a technical approach(More)
AIMS Epoxyeicosatrienoic acids (EETs) are cytochrome P450 epoxygenase metabolites of arachidonic acid that have known cardioprotective properties. While the mechanism(s) remains unknown, evidence suggests that phosphoinositide 3-kinase (PI3K) and sarcolemmal ATP-sensitive potassium channels (pmK(ATP)) are important. However the role of specific PI3K(More)
This paper develops and empirically implements an arbitrage-free, dynamic term structure model with " priced " factor and regime-shift risks. The risk factors are assumed to follow a discrete-time Gaussian process, and regime shifts are governed by a discrete-time Markov process with state-dependent transition probabilities. This model gives closed-form(More)
Mobile malware attempts to evade detection during app analysis by mimicking security-sensitive behaviors of benign apps that provide similar functionality (e.g., sending SMS messages), and suppressing their payload to reduce the chance of being observed (e.g., executing only its payload at night). Since current approaches focus their analyses on the types(More)