Wei-Wen Chang

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Overexpression of Shc adaptor proteins is associated with mitogenesis, carcinogenesis and metastasis. Multiple copies in T-cell malignancy 1 (MCT-1) oncoprotein promotes cell proliferation, survival and tumorigenic effects. Our current data show that MCT-1 is a novel regulator of Shc-Ras-MEK-ERK signaling and MCT-1 is significantly co-activated with Shc(More)
AIMS Mitochondrial succinate dehydrogenase (SDH) is an essential complex of the electron transport chain and tricarboxylic acid cycle. Mutations in the human SDH subunit D frequently lead to paraganglioma (PGL), but the mechanistic consequences of the majority of SDHD polymorphisms have yet to be unraveled. In addition to the originally discovered yeast(More)
In order to conform to the real world systems such as distribution systems and supply chain management system, we assume the capacity of each arc in the quickest path problem is stochastic (multi-state). In this study, we propose a simple algorithm to evaluate the probability that d units of data can be sent from the source node to the sink node through the(More)
In this paper we combine the main concepts of estimation of distribution algorithms (EDAs) and immune algorithms (IAs) to be a hybrid algorithm called immune-estimation of distribution algorithms (IEDA). Both EDAs and IAs are extended from genetic algorithms (GAs). EDAs eliminate the genetic operation including crossover and mutation from the GAs and places(More)
Background construction is the base of object detection and tracking for the machine vision system. Traditional background modeling methods often require complicated computations and are sensitive to illumination changes and shadow interference. In this paper, we propose a block-based background modeling method, which fully utilizes the color and texture(More)
Centrosome amplification and chromosome abnormality are frequently identified in neoplasia and tumorigenesis. However, the mechanisms underlying these defects remain unclear. We here identify that MCT-1 is a centrosomal oncoprotein involved in mitosis. Knockdown of MCT-1 protein results in intercellular bridging, chromosome mis-congregation, cytokinesis(More)
Microarray data analysis is a major line of research in bioinformatics. A significant trend in bioinformatics is identifying genes or gene groups that differentiate diseased tissues. Classification is necessary to make microarray data useful for application in medicine, and in related research such as disease diagnosis. Classification models have been(More)
Our hospital was the first institution to offer cytoreduction surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) in Taiwan. Therefore, we report our experience and outcomes among patients who underwent HIPEC.Since 2002, 164 eligible patients underwent HIPEC, and we excluded cases of laparoscopic or prophylactic HIPEC. The cases were(More)