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Cloud resources are usually priced in multiple markets with different service guarantees. For example, Amazon EC2 prices virtual instances under three pricing schemes -- the subscription option (a.k.a., Reserved Instances), the pay-as-you-go offer (a.k.a., On-Demand Instances), and an auction-like spot market (a.k.a., Spot Instances) -- simultaneously.(More)
—Cloud service pricing plays a pivotal role towards the success of cloud computing. Existing pricing schemes, however , either provide no service guarantees (e.g., Spot Instances in Amazon EC2), or use static on-demand pricing in which the price cannot respond quickly to market dynamics (e.g., On-demand Instances in Amazon EC2). To overcome these problems,(More)
Infrastructure-as-a-Service clouds offer diverse pricing options, including on-demand and reserved instances with various discounts to attract different cloud users. A practical problem facing cloud users is how to minimize their costs by choosing among different pricing options based on their own demands. In this paper, we propose a new cloud brokerage(More)
Market-driven spectrum auctions offer an efficient way to improve spectrum utilization by transferring unused or under-used spectrum from its primary license holder to spectrum-deficient secondary users. Such a spectrum market exhibits strong locality in two aspects: 1) that spectrum is a local resource and can only be traded to users within the license(More)
We study the multi-resource allocation problem in cloud computing systems where the resource pool is constructed from a large number of heterogeneous servers, representing different points in the configuration space of resources such as processing, memory, and storage. We design a multi-resource allocation mechanism, called DRFH, that generalizes the notion(More)
We study the multi-resource allocation problem in cloud computing systems where the resource pool is constructed from a large number of heterogeneous servers, representing different points in the configuration space of resources such as processing, memory, and storage. We design a multi-resource allocation mechanism, called DRFH, that generalizes the notion(More)
Colorectal carcinoma (CRC) is a major cause of cancer mortality. The aberrant expression of several microRNAs is associated with CRC progression; however, the molecular mechanisms underlying this phenomenon are unclear. miR-638 and SRY-box 2 (SOX2) expression levels were detected in 36 tumor samples and their adjacent, non-tumor tissues from patients with(More)
—Providing quality-of-service guarantees by means of fair sharing has never been more challenging in datacenters. Due to the heterogeneity of machine configurations, datacenter jobs frequently specify placement constraints, restricting them to run on a particular class of machines meeting specific hardware/software requirements. In addition, jobs have(More)
—Infrastructure-as-a-Service (IaaS) clouds offer diverse instance purchasing options. A user can either run instances on demand and pay only for what it uses, or it can prepay to reserve instances for a long period, during which a usage discount is entitled. An important problem facing a user is how these two instance options can be dynamically combined to(More)
Lysosomal associated membrane protein 3 (LAMP3) is a newly identified tumor-specific protein. It is a downstream target gene of tumor suppressor TP53 and its expression has been associated with hypoxia-induced metastasis and poor overall survival in cervical and breast cancers. However, little is known of LAMP3 protein expression in gastrointestinal cancer(More)