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Eukaryotic gene transcription is accompanied by acetylation and methylation of nucleosomes near promoters, but the locations and roles of histone modifications elsewhere in the genome remain unclear. We determined the chromatin modification states in high resolution along 30 Mb of the human genome and found that active promoters are marked by trimethylation(More)
PIWI-interacting RNAs (piRNAs) protect the animal germ line by silencing transposons. Primary piRNAs, generated from transcripts of genomic transposon "junkyards" (piRNA clusters), are amplified by the "ping-pong" pathway, yielding secondary piRNAs. We report that secondary piRNAs, bound to the PIWI protein Ago3, can initiate primary piRNA production from(More)
Over years, virtual backbone has attracted lots of attentions as a promising approach to deal with the broadcasting storm problem in wireless networks. One popular way to construct a quality virtual backbone is to solve the minimum connected dominating set problem. However, a virtual backbone computed in this way is not resilient against topology change(More)
In Drosophila ovarian germ cells, PIWI-interacting RNAs (piRNAs) direct Aubergine and Argonaute3 to cleave transposon transcripts and instruct Piwi to repress transposon transcription, thereby safeguarding the germline genome. Here, we report that RNA cleavage by Argonaute3 initiates production of most Piwi-bound piRNAs. We find that the cardinal function(More)
T-2 toxin is regarded as an important etiological factor of Kashin-Beck disease, and supplementation of selenium-salt partly prevents Kashin-Beck disease. The present study investigated the effects of T-2 toxin on the degradation of type II collagen in human chondrocytes in vitro. Human chondrocytes were isolated and cultured on bone matrix gelatin to form(More)
A Virtual Backbone (VB) of a wireless network is a subset of nodes such that only VB nodes are responsible for routing-related tasks. Since a smaller VB causes less overhead, size is the primary quality factor of VB. Frequently, Unit Disk Graphs (UDGs) are used to model 2D homogeneous wireless networks, and the problem of finding minimum VBs in the networks(More)
Chinese herbal medicines possess the therapeutic potential for mood disorders. This double-blind, randomized, placebo-controlled study was designed to evaluate the efficacy and side effects of the herbal medicine called Free and Easy Wanderer Plus (FEWP) as an adjunct to carbamazepine (CBZ) in patients with bipolar disorders. One hundred and twenty-four(More)
—Neighbor discovery (ND) is a basic and crucial step for initializing wireless ad hoc networks. A fast, precise, and energy-efficient ND protocol has significant importance to subsequent operations in wireless networks. However, many existing protocols have a high probability of generating idle slots in their neighbor discovering processes, which prolongs(More)
This study investigated the mechanism underlying electroacupuncture therapy for vascular dementia through electroacupuncture at the acupoints of Baihui (DU20), Dazhui (DU14), and bilateral Shenshu (BL23) in a rat model of vascular dementia produced by bilateral middle cerebral artery occlusion. Morris water maze test showed that electroacupuncture improved(More)