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Privacy becomes a more and more serious concern in applications involving microdata. Recently, efficient anonymization has attracted much research work. Most of the previous methods use global recoding, which maps the domains of the quasi-identifier attributes to generalized or changed values. However, global recoding may not always achieve effective(More)
The emerging data mining tools and systems lead naturally to the demand of a powerful data mining query language, on top of which many i n teractive and exible graphical user interfaces can be developed. This motivates us to design a data mining query language, DMQL, for mining diierent kinds of knowledge in relational databases. Portions of the proposed(More)
Constraints are essential for many sequential pattern mining applications. However, there is no systematic study on <i>constraint-based sequential pattern mining</i>. In this paper, we investigate this issue and point out that the framework developed for constrained frequent-pattern mining does not fit our missions well. An extended framework is developed(More)
PURPOSE Panax ginseng and its extracts have long been used for medical purposes; there is increasing interest in developing ginseng products as cancer preventive or therapeutic agents. The present study was designed to determine biological structure-activity relationships (SAR) for saponins present in Panax ginseng fruits. METHODS Eleven saponins were(More)
Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel, an ATP binding cassette (ABC) transporter. CFTR gating is linked to ATP binding and dimerization of its two nucleotide binding domains (NBDs). Channel activation also requires phosphorylation of the R domain by poorly understood mechanisms.(More)
MEKK1-deficient mice show an eye open at birth phenotype caused by impairment in embryonic eyelid closure. MEK kinase 1 (MEKK1) is highly expressed in the growing tip of the eyelid epithelium, which displays loose cell-cell contacts and prominent F-actin fibers in wild-type mice, but compact cell contacts, lack of polymerized actin and a concomitant(More)
Neuropathic pain is a refractory disease characterized by maladaptive changes in gene transcription and translation in the sensory pathway. Long noncoding RNAs (lncRNAs) are emerging as new players in gene regulation, but how lncRNAs operate in the development of neuropathic pain is unclear. Here we identify a conserved lncRNA, named Kcna2 antisense RNA,(More)
The deletion of phenylalanine 508 in the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator is directly associated with >90% of cystic fibrosis cases. This mutant protein fails to traffic out of the endoplasmic reticulum and is subsequently degraded by the proteasome. The effects of this mutation may be partially(More)
Mining frequent structural patterns from graph databases is an interesting problem with broad applications. Most of the previous studies focus on pruning unfruitful search subspaces effectively, but few of them address the mining on large, disk-based databases. As many graph databases in applications cannot be held into main memory, scalable mining of(More)
Mining frequent tree patterns is an important research problems with broad applications in bioinformatics, digital library, e-commerce, and so on. Previous studies highly suggested that pattern-growth methods are efficient in frequent pattern mining. In this paper, we systematically develop the pattern growth methods for mining frequent tree patterns. Two(More)