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BACKGROUND Glutathione S-transferases (GSTs) play an important role in metabolizing anti-epileptic drugs (AEDs) in liver. Expressions of GSTs in brain, which may result in poor efficacy of AEDs, have not been well studied. Using clinical cortex specimen from 32 intractable epileptic subjects and 8 non-epileptic controls, the present study investigated the(More)
Temporal lobe epilepsy (TLE), characterized by spontaneous recurrent seizure (SRS), is associated with behavioural problems, but the underlying molecular mechanisms have not been clearly identified. In the present study, kainic acid (KA) was administered systemically in adult male Wistar rats to induce SRS. Behavioural performance analyses at 2, 4, and 6(More)
To further confirm at the molecular level that neuronal apoptosis occurs in mesial temporal sclerosis (MTS), the main substrate of mesial temporal lobe epilepsy (MTLE), 24 resected sclerotic hippocampi from 24 patients with drug-resistant MTLE associated with MTS were studied microscopically, electronmicroscopically and immunohistochemically, with detection(More)
We retrospectively evaluated the clinical and electroencephalogram (EEG) characteristics of benign rolandic epilepsy (BRE) in Chinese children. Two hundred and seventy-six patients with BRE were enrolled in this study. All patients had their first seizure between the ages of 3 and 12 years. 39.5% (109 cases) of patients ceased to have further BRE seizures(More)
OBJECTIVES Adverse drug reactions (ADRs) are believed to be a leading cause of death in the world. Pharmacovigilance systems are aimed at early detection of ADRs. With the popularity of social media, Web forums and discussion boards become important sources of data for consumers to share their drug use experience, as a result may provide useful information(More)
Public attention on natural gas price, which reflects the demand dynamics, is considered as a new factor to influence the movement of price. So investigate the impact of public attention on natural gas price is an innovative research issue in energy economics. This paper innovatively constructs a measure of public attention and examines its impact on(More)
Performance testing is conducted before deploying system updates in order to ensure that the performance of large software systems did not degrade (i.e., no performance regressions). During such testing, thousands of performance counters are collected. However, comparing thousands of performance counters across versions of a software system is very time(More)
Temporal lobe epilepsy is characterized by spontaneous recurrent seizures (SRS) and associated with behavioral problems. However, the molecular mechanisms underlying these problems are not yet clear. In this study, kainic acid (KA) was systemically administered to immature male Wistar rats to induce SRS. The behavior of the immature rats was evaluated with(More)