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Cloning and characterisation of two natural killer enhancing factor genes (NKEF-A and NKEF-B) in pufferfish, Tetraodon nigroviridis.
TLDR
This is the first report on the existence of a NKEF-B homologue in fish, and the deduced amino acids of the two genes are highly homologous with mammalian NkeF-A and NKEf-B proteins, including two well conserved Val-Cys-Pro motifs.
Genome Sequencing of the Perciform Fish Larimichthys crocea Provides Insights into Molecular and Genetic Mechanisms of Stress Adaptation
TLDR
The results reveal the molecular and genetic basis of fish adaptation and response to hypoxia and air exposure, and reveal new aspects of neuro-endocrine-immune/metabolism regulatory networks that may help the fish to avoid cerebral inflammatory injury and maintain energy balance under Hypoxia.
Deep sequencing-based transcriptome profiling analysis of bacteria-challenged Lateolabrax japonicus reveals insight into the immune-relevant genes in marine fish
TLDR
An overall conservation of the components and transcriptome alterations underlying innate and adaptive immunity in fish and other vertebrate models is indicated, suggesting the acquisition of numerous fish-specific immune system components during early vertebrate evolution.
Characterization of surface phenotypic molecules of teleost dendritic cells.
TLDR
P phenotypic and functional characteristics of teleost DCs were described in a zebrafish model and functional analysis results showed that DrDCs could initiate antigen-specific CD4(+) T cell activation, in which MHC-II, CD80/86, CD83, and CD209 are implicated.
The DC-SIGN of Zebrafish: Insights into the Existence of a CD209 Homologue in a Lower Vertebrate and Its Involvement in Adaptive Immunity1
TLDR
Phylogenetic analysis supports the hypothesis that CD209 family members diverged from a common ancestor and shows that the expression of DC-SIGN/CD209 in immune-related tissues can be significantly up-regulated by exogenous Ags and IL-4.
IL-16 Induces Intestinal Inflammation via PepT1 Upregulation in a Pufferfish Model: New Insights into the Molecular Mechanism of Inflammatory Bowel Disease
TLDR
This study reports for the first time the mechanism by which IL-16 induces intestinal inflammation by upregulating the expression of oligopeptide transporter member 1 (PepT1) in a Tetraodon nigroviridis fish model and suggests that fish species are an attractive model for studying IBD.
B Cells in Teleost Fish Act as Pivotal Initiating APCs in Priming Adaptive Immunity: An Evolutionary Perspective on the Origin of the B-1 Cell Subset and B7 Molecules
TLDR
Zebrafish B cells clearly showed a potent Ag-presenting ability to both soluble Ags and bacterial particles to prime naive CD4+ T cell activation, demonstrating the innate-like nature of teleost B cells in the interface of innate and adaptive immunity, and suggesting the costimulatory mechanism originated as early as the origin of adaptive immunity.
Novel Antibiotic-Free Plasmid Selection System Based on Complementation of Host Auxotrophy in the NAD De Novo Synthesis Pathway
TLDR
A novel auxotrophy complementation system that allowed plasmids and host cells to be effectively selected and maintained without the use of antibiotics is introduced.
Characterization of an NLRP1 Inflammasome from Zebrafish Reveals a Unique Sequential Activation Mechanism Underlying Inflammatory Caspases in Ancient Vertebrates
TLDR
The molecular and functional identification of an NLRP1 homolog, Danio rerio NL RP1 (DrNLRP1) from a zebrafish model, and its verified to play important functional roles in antibacterial innate immunity in vivo demonstrate that the NLRP 1 inflammasome originated as early as in teleost fish.
Discovery of the DIGIRR Gene from Teleost Fish: A Novel Toll–IL-1 Receptor Family Member Serving as a Negative Regulator of IL-1 Signaling
TLDR
It is suggested that DIGIRR might be an evolutionary “transitional molecule” between IL-1R and SIGIRR, representing a shift from a potent receptor to a negative regulator in the evolutionary history of TIR family members and their associated signaling pathways and mechanisms.
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