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Broadcast is an important operation in many network protocols. It is utilized to discover routes to unknown nodes in mobile ad hoc networks (MANETs) and is the key factor in scaling on-demand routing protocols to large networks. This paper presents the Ad Hoc Broadcast Protocol (AHBP) and its performance is discussed. In the protocol, messages are only(More)
Visual clutter denotes a disordered collection of graphical entities in information visualization. Clutter can obscure the structure present in the data. Even in a small dataset, clutter can make it hard for the viewer to find patterns, relationships and structure. In this paper, we define visual clutter as any aspect of the visualization that interferes(More)
Large number of dimensions not only cause clutter in multi-dimensional visualizations, but also make it difficult for users to navigate the data space. Effective dimension management, such as dimension ordering, spacing and filtering, is critical for visual exploration of such datasets. Dimension ordering and spacing explicitly reveal dimension(More)
Enterovirus 71 (EV71) is a major agent of hand, foot and mouth disease in children that can cause severe central nervous system disease and death. No vaccine or antiviral therapy is available. High-resolution structural analysis of the mature virus and natural empty particles shows that the mature virus is structurally similar to other enteroviruses. In(More)
Chromosome movements in mitosis are orchestrated by dynamic interactions between spindle microtubules and the kinetochore, a multiprotein complex assembled onto centromeric DNA of the chromosome. Here we show that phosphorylation of human HsMis13 by Aurora B kinase is required for functional kinetochore assembly in HeLa cells. Aurora B interacts with(More)
The ryanodine receptors (RyRs) are high-conductance intracellular Ca(2+) channels that play a pivotal role in the excitation-contraction coupling of skeletal and cardiac muscles. RyRs are the largest known ion channels, with a homotetrameric organization and approximately 5,000 residues in each protomer. Here we report the structure of the rabbit RyR1 in(More)
Pancreatic cancer (PC) is the fourth leading cause of cancer-related mortalities in the USA and the sixth leading cause of mortality in China. Recent studies have shown that lncRNAs play important roles in carcinogenesis. The aim of this study was to explore the role of lncRNA HULC in PC. Quantitative real-time PCR was performed to investigate the(More)
Least mean square (LMS) based adaptive algorithms have been attracted much attention since their low computational complexity and robust recovery capability. To exploit the channel sparsity, LMS-based adaptive sparse channel estimation methods, e.g., zero-attracting LMS (ZA-LMS), reweighted zero-attracting LMS (RZA-LMS) and L<inf>p</inf> - norm sparse LMS(More)
RIP3 is an essential upstream kinase in necroptosis. The pseudokinase MLKL functions as a substrate of RIP3 to mediate downstream signaling. The molecular mechanism by which RIP3 recognizes and phosphorylates MLKL remains unknown. Here, we report the crystal structures of the mouse RIP3 kinase domain, the MLKL kinase-like domain, and a binary complex(More)