Learn More
MOTIVATION We consider the detection of expressed genes and the comparison of them in different experiments with the high-density oligonucleotide microarrays. The results are summarized as the detection calls and comparison calls, and they should be robust against data outliers over a wide target concentration range. It is also helpful to provide parameters(More)
MOTIVATION Analysis of many thousands of single nucleotide polymorphisms (SNPs) across whole genome is crucial to efficiently map disease genes and understanding susceptibility to diseases, drug efficacy and side effects for different populations and individuals. High density oligonucleotide microarrays provide the possibility for such analysis with(More)
1998). 'More difficult' refers to the fact that, compared with the structural class prediction, the odds are much lower for the secondary structure content prediction. In the former case, few possible clusters. In the latter case, however, the prediction IN 46202-5132, USA has to deal with a target of continuous quantity, i.e. to 2 To whom correspondence(More)
BACKGROUND MicroRNAs (miRNAs) are small non-coding RNA molecules capable of regulating transcription and translation. Previously, a cluster of miRNAs that are specifically expressed in mouse zygotes but not in oocytes or other preimplantation stages embryos are identified by multiplex real-time polymerase chain reaction-based miRNA profiling. The functional(More)
This is supplemental data extracted from the paper Robust Estimators for Expression Analysis and provided on this web-site. One advantage of using a logarithmic transformation is that it approximately stabilizes the variance of the resulting estimate. This stabilization can be observed in figure 1. Note that as expected, this approximation breaks down at(More)
MicroRNAs interact with multiple mRNAs resulting in their degradation and/or translational repression. This report used the delayed implantation model to determine the role of miRNAs in blastocysts. Dormant blastocysts in delayed implanting mice were activated by estradiol. Differential expression of 45 out of 238 miRNAs examined was found between the(More)
In this work we demonstrate that functional infrared imaging is capable of detecting low frequency temperature fluctuations in intact human skin and revealing spatial, temporal, spectral, and time-frequency based differences among three tissue classes: microvasculature, large sub-cutaneous veins, and the remaining surrounding tissue of the forearm. We found(More)
—Thermal Signal Reconstruction (TSR) is a well-known nondestructive evaluation technique. It enhances the locations of defects in composite materials in aerospace industry, and has been applied in infrared imaging of human hands recently to locate microvasculature under the skin. In this work we reinvestigated the new application and explored the(More)