Learn More
The C-aryl glucoside 6 (dapagliflozin) was identified as a potent and selective hSGLT2 inhibitor which reduced blood glucose levels in a dose-dependent manner by as much as 55% in hyperglycemic streptozotocin (STZ) rats. These findings, combined with a favorable ADME profile, have prompted clinical evaluation of dapagliflozin for the treatment of type 2(More)
This paper studies the name lookup issue with longest prefix matching, which is widely used in URL filtering, content routing/switching, etc. Recently Content-Centric Networking (CCN) has been proposed as a clean slate future Internet architecture to naturally fit the content-centric property of today's Internet usage: instead of addressing end hosts, the(More)
Name-based route lookup is a key function for Named Data Networking (NDN). The NDN names are hierarchical and have variable and unbounded lengths, which are much longer than IPv4/6 address, making fast name lookup a challenging issue. In this paper, we propose an effective Name Component Encoding (NCE) solution with the following two techniques: (1) A code(More)
We describe a novel and effective video enhancement algorithm for low lighting video. The algorithm works by first inverting the input low-lighting video and then applying an image de-haze algorithm on the inverted input. To facilitate faster computation and improve temporal consistency, correlations between temporally neighboring frames are utilized.(More)
Given their critical role as gateways to Web content, the search results a Web search engine provides to its users have an out-sized impact on the way each user views the Web. Previous studies have shown that popular Web search engines like Google employ sophisticated personalization engines that can occasionally provide dramatically inconsistent views of(More)
In this study, hydrogen peroxide was used to study the oxidation of rhRlx under various conditions. Oxidation of rhRlx occurred at both of the two methionines on the B chain, Met B(4) and Met B(25), as expected from the three-dimensional structure of the molecule, which shows that these two residues are located on the surface of the molecule and exposed to(More)
Stem cell-based therapy is a promising intervention for ischemic heart diseases. However, the functional integrity of stem cells is impaired in an ischemic environment. Here, we report a novel finding that heat shock significantly improves Sca-1(+) stem cell survival in an ischemic environment by the regulation of the triangle: heat shock factor 1 (HSF1),(More)
OBJECTIVE The inhibition of gut and renal sodium-glucose cotransporters (SGLTs) has been proposed as a novel therapeutic approach to the treatment of diabetes. We have identified dapagliflozin as a potent and selective inhibitor of the renal sodium-glucose cotransporter SGLT2 in vitro and characterized its in vitro and in vivo pharmacology. RESEARCH(More)
Promoter hypermethylation, a widely studied epigenetic event known to influence gene expression levels, has been proposed as a potential biomarker in multiple types of cancer. Clinical diagnostic biomarkers are needed for reliable prediction of bladder cancer recurrence. In this paper, DNA promoter methylation of five C-terminal Ras-association family(More)
Quadricuspid aortic valve is a rare congenital malformation of the aortic valve. Its diagnosis is often missed even with the use of transthoracic echocardiogram. Many of these patients progress to aortic incompetence later in life, hence requiring surgical intervention. In the case described in this report, a 61-year-old woman is presented with the features(More)