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To distinguish the real pre-miRNAs from other hairpin sequences with similar stem-loops (pseudo pre-miRNAs), a hybrid feature which consists of local contiguous structure-sequence composition, minimum of free energy (MFE) of the secondary structure and P-value of randomization test is used. Besides, a novel machine-learning algorithm, random forest (RF), is(More)
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pulmonary haemorrhages, including fatal sudden haemoptysis, can occur. Here we report the complete genomic sequence of a representative virulent serovar(More)
Plant innate immune response to pathogen infection includes an elegant signaling pathway leading to reactive oxygen species generation and resulting hypersensitive response (HR); localized programmed cell death in tissue surrounding the initial infection site limits pathogen spread. A veritable symphony of cytosolic signaling molecules (including Ca(2+),(More)
We discuss Web Service Management (WSM) and Web Service Composition Management (WSCM) applications of the Web Service Offerings Language (WSOL) and how the language supports these applications. WSOL is a language for the formal specification of classes of service, various constraints (functional constraints, Quality of Service—QoS, and access rights), and(More)
RxNorm: Prescription for Electronic Drug Information Exchange T oday’s commercial drug information sys­ tems follow a variety of naming conven­ tions. For example, cooperating hospitals might use different systems, and find their data incompatible. Even within a hospital, there might be one system for ordering, another for inventory management, and still(More)
Long noncoding RNAs (lncRNAs) represent a big category of noncoding RNA molecules, and increasing studies have shown that they play important roles in various critical biological processes. They show a diversity of functions through diverse mechanisms, among which regulating RNA molecules is one of the most popular ones. Given the big number of lncRNAs, it(More)
Plant cells sensing pathogenic microorganisms evoke defence systems that can confer resistance to infection. This innate immune reaction can include triggering of basal defence responses as well as programmed cell death, or hypersensitive response (HR). In both cases (basal defence and HR), pathogen perception is translated into elevated cytosolic Ca(2+)(More)
MicroRNAs (miRNAs) are small non-coding RNA molecules, which act as post-transcriptional regulators of gene expression and have been implicated in initiation, progression and treatment outcome of diverse cancers. Single nucleotide polymorphisms (SNPs), as the most common type of genetic variation, also exist in miRNA genes and can lead to alteration in(More)
Ca(2+) influx is an early signal initiating cytosolic immune responses to pathogen perception in plant cells; molecular components linking pathogen recognition to Ca(2+) influx are not delineated. Work presented here provides insights into this biological system of non-self recognition and response activation. We have recently identified a cyclic(More)
Ca(2+) rise and nitric oxide (NO) generation are essential early steps in plant innate immunity and initiate the hypersensitive response (HR) to avirulent pathogens. Previous work from this laboratory has demonstrated that a loss-of-function mutation of an Arabidopsis (Arabidopsis thaliana) plasma membrane Ca(2+)-permeable inwardly conducting ion channel(More)