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To distinguish the real pre-miRNAs from other hairpin sequences with similar stem-loops (pseudo pre-miRNAs), a hybrid feature which consists of local contiguous structure-sequence composition, minimum of free energy (MFE) of the secondary structure and P-value of randomization test is used. Besides, a novel machine-learning algorithm, random forest (RF), is(More)
T oday's commercial drug information sys­ tems follow a variety of naming conven­ tions. For example, cooperating hospitals might use different systems, and find their data incompatible. Even within a hospital, there might be one system for ordering, another for inventory management, and still another for recording dose adjustments or checking drug(More)
We discuss Web Service Management (WSM) and Web Service Composition Management (WSCM) applications of the Web Service Offerings Language (WSOL) and how the language supports these applications. WSOL is a language for the formal specification of classes of service, various constraints (functional constraints, Quality of Service—QoS, and access rights), and(More)
Our Web Service Offerings Language (WSOL) enables formal specification of important management information - classes of service (modeled as service offerings), various types of constraint (functional, QoS, access rights), and management statements (e.g., prices, penalties, and management responsibilities) - for XML (Extensible Markup Language) Web services.(More)
Published literature reports controversial results about the association of physical activity (PA) with risk of hypertension. A meta-analysis of prospective cohort studies was performed to investigate the effect of PA on hypertension risk. PubMed and Embase databases were searched to identify all related prospective cohort studies. The Q test and I(2)(More)
Defects in meiotic spindle structure contribute to chromosome segregation errors leading to genomic instability in oocytes and embryos upon fertilization. In this study, we analyzed the mechanisms that control spindle microtubule nucleation and stability in mammalian oocytes, and identified NEDD1/GCP-WD as a key regulator. NEDD1 specifically co-localizes(More)
BACKGROUND This study was conducted to ascertain the feasibility of using rapid oral fluid testing as an alternative HIV testing method in China. METHOD This is a mixed-method study among men who have sex with men (MSM), female sex workers (FSW) and VCT clients, conducted in 4 cities in Shandong Province. A pre-tested questionnaire was administered to(More)
PURPOSE To study posterior choroidal thickness and its profile based on location in a healthy Chinese population and to determine its correlation with age and refractive error. METHODS A total of 210 healthy volunteers (420 eyes) with no ophthalmic disease history were recruited. Choroidal scans were obtained for all eyes using enhanced depth imaging(More)
A series of methyllycaconitine (1a, MLA) analogs was synthesized where the (S)-2-methylsuccinimidobenzoyl group in MLA was replaced with a (R)-2-methyl, 2,2-dimethyl-, 2,3-dimethyl, 2-phenyl-, and 2-cyclohexylsuccinimidobenzoyl (1b-f) group. The analogs 1b-f were evaluated for their inhibition of [(125)I]iodo-MLA binding at rat brain alpha7 nicotinic(More)
A number of 2',3'-disubstituted epibatidine analogues were synthesized and evaluated in vitro for potency at nicotinic acetylcholine receptors (nAChRs) and in vivo for antinociception activity in the tail-flick and hot-plate models of acute pain and for their ability to affect core body temperature. Compounds that possessed electron-withdrawing groups (F,(More)