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OBJECTIVE To assess the effect of lifestyle intervention over 2 years on changes in weight, coronary heart disease (CHD) risk factors, and incidence of diabetes in overweight individuals with a parental history of diabetes. RESEARCH DESIGN AND METHODS Participants (n = 154), who were 30-100% over ideal body weight, had one or both parents with diabetes,(More)
INTRODUCTION The Psoriasis Area and Severity Index (PASI) is the most widely used tool to assess psoriasis disease severity in clinical trials, although it can be exceedingly cumbersome for use in daily clinical practice. Because clinical trials rely on the PASI for inclusion criteria, having a PASI score on a clinic patient may be useful for determining if(More)
BACKGROUND The positive association between body weight and bone mineral density (BMD) is well documented; in contrast, the effect of changes in body weight on BMD is not well understood, particularly, in normal-weight populations. OBJECTIVE We examined the effect of a lifestyle intervention aimed at lowering dietary fat intake and increasing physical(More)
CONTEXT The prevalence of severe obesity is increasing markedly, as is prevalence of comorbid conditions such as hypertension and type 2 diabetes mellitus; however, apart from bariatric surgery and pharmacotherapy, few clinical trials have evaluated the treatment of severe obesity. OBJECTIVE To determine the efficacy of a weight loss and physical activity(More)
CONTEXT A higher duration and intensity of exercise may improve long-term weight loss. OBJECTIVE To compare the effects of different durations and intensities of exercise on 12-month weight loss and cardiorespiratory fitness. DESIGN, SETTING, AND PARTICIPANTS Randomized trial conducted from January 2000 through December 2001 involving 201 sedentary(More)
This study identified predictors of weight gain versus continued maintenance among individuals already successful at long-term weight loss. Weight, behavior, and psychological information was collected on entry into the study and 1 year later. Thirty-five percent gained weight over the year of follow-up, and 59% maintained their weight losses. Risk factors(More)
AIMS The aim of this study was to analyze patients' port-related quality of life. PATIENTS AND METHODS 260 consecutive patients with gynecological or breast malignancies were asked to take part in a questionnaire-based survey including 26 questions, and 232 women agreed to participate in the study. The questionnaire inquired about port-related aspects of(More)
Glycomics-an integrated approach to study structure-function relationships of complex carbohydrates (or glycans)-is an emerging field in this age of post-genomics. Realizing the importance of glycomics, many large scale research initiatives have been established to generate novel resources and technologies to advance glycomics. These initiatives are(More)
OBJECTIVE This paper describes and examines conceptually relevant correlates of health-related quality of life (HRQL) in overweight or obese persons with type 2 diabetes. Research Design and Procedures: The investigation was a cross-sectional study of 5145 overweight or obese adults with type 2 diabetes between the ages of 45 and 74 years. Analyses examined(More)
CONTEXT Enhancing participation in long-term exercise may translate into improved long-term weight loss in overweight adults. OBJECTIVES To compare the effects of intermittent with traditional continuous exercise on weight loss, adherence, and fitness, and to examine the effect of combining intermittent exercise with that using home exercise equipment. (More)