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We have developed a high-throughput method for analyzing the methylation status of hundreds of preselected genes simultaneously and have applied it to the discovery of methylation signatures that distinguish normal from cancer tissue samples. Through an adaptation of the GoldenGate genotyping assay implemented on a BeadArray platform, the methylation state(More)
This paper presents evolvable block-based neural networks (BbNNs) for personalized ECG heartbeat pattern classification. A BbNN consists of a 2-D array of modular component NNs with flexible structures and internal configurations that can be implemented using reconfigurable digital hardware such as field-programmable gate arrays (FPGAs). Signal flow between(More)
Microtubule (MT)-based motor proteins, kinesins and dyneins, play important roles in multiple cellular processes including cell division. In this study, we describe the generation and use of an Escherichia coli RNase III-prepared human kinesin/dynein esiRNA library to systematically analyze the functions of all human kinesin/dynein MT motor proteins. Our(More)
The spindle midzone, a conspicuous network of antiparallel interdigitating nonkinetochore microtubules between separating chromosomes, plays a crucial role in regulating the initiation and completion of cytokinesis. In this study, we report the use of time-lapse microscopy and a human kinesin endoribonucleases RNase III-prepared short interfering RNA(More)
High Efficiency Video Coding (HEVC) is an ongoing video compression standard and a successor to H.264/AVC. It aims to provide significantly improved compression performance as compared to all existing video coding standards. In the intra prediction of HEVC, this is being achieved by providing up to 35 intra modes with larger coding unit. The optimal mode is(More)
k-anonymity provides a measure of privacy protection by preventing re-identification of data to fewer than a group of k data items. While algorithms exist for producing k-anonymous data, the model has been that of a single source wanting to publish data. Due to privacy issues, it is common that data from different sites cannot be shared directly. Therefore,(More)
For the past decade, query processing on relational data has been studied extensively, and many theoretical and practical solutions to query processing have been proposed under various scenarios. With the recent popularity of cloud computing, users now have the opportunity to outsource their data as well as the data management tasks to the cloud. However,(More)
The significance of elevated plasma levels of bacterial lipopolysaccharide (LPS) in persons with chronic HIV infection remains undefined. We measured LPS levels by use of limulus lysate assay, and DNA sequences encoding bacterial ribosomal 16S RNA (16S rDNA) were assessed by quantitative polymerase chain reactions in plasma samples obtained from 242 donors.(More)
Toxicity of nano-scaled aluminum, silicon, titanium and zinc oxides to bacteria (Bacillus subtilis, Escherichia coli and Pseudomonas fluorescens) was examined and compared to that of their respective bulk (micro-scaled) counterparts. All nanoparticles but titanium oxide showed higher toxicity (at 20 mg/L) than their bulk counterparts. Toxicity of released(More)
Abstract—Automatic service composition has been a hottopic in both academia and industry. It begins with syntacticcomposition, and then evolves semantic description. Recently, QoS of the composition comes into researchers’ mind, which aims at meeting the need of the overall qualities like service fee, response time, throughput, etc. In this(More)