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The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory(More)
In this paper, we propose a novel robust line orientation code for palmprint verification, whose performance is improved by using three strategies. Firstly, a modified finite Radon transform (MFRAT) is proposed, which can extract the orientation feature of palmprint more accurately and solve the problem of sub-sampling better. Secondly, we construct an(More)
In this brief, a novel local descriptor, named local binary count (LBC), is proposed for rotation invariant texture classification. The proposed LBC can extract the local binary grayscale difference information, and totally abandon the local binary structural information. Although the LBC codes do not represent visual microstructure, the statistics of LBC(More)
In this paper, we propose a novel palmprint verification approach based on principal lines. In feature extraction stage, the modified finite Radon transform is proposed, which can extract principal lines effectively and efficiently even in the case that the palmprint images contain many long and strong wrinkles. In matching stage, a matching algorithm based(More)
Humans have evolved intimate symbiotic relationships with a consortium of gut microbes (microbiome) and individual variations in the microbiome influence host health, may be implicated in disease etiology, and affect drug metabolism, toxicity, and efficacy. However, the molecular basis of these microbe-host interactions and the roles of individual bacterial(More)
In this brief, we propose a novel contour-based shape descriptor, called the multiscale distance matrix, to capture the shape geometry while being invariant to translation, rotation, scaling, and bilateral symmetry. The descriptor is further combined with a dimensionality reduction to improve its discriminative power. The proposed method avoids the(More)
Colorectal carcinogenesis involves the overexpression of many immediate-early response genes associated with growth and inflammation, which significantly alters downstream protein synthesis and small-molecule metabolite production. We have performed a serum metabolic analysis to test the hypothesis that the distinct metabolite profiles of malignant tumors(More)
Hepatocellular carcinoma (HCC) is a common malignancy in the world with high morbidity and mortality rate. Identification of novel biomarkers in HCC remains impeded primarily because of the heterogeneity of the disease in clinical presentations as well as the pathophysiological variations derived from underlying conditions such as cirrhosis and(More)
SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties by modifications to the amide portion of the molecule resulting in 31 (GDC-0449). Amide 31 produced complete(More)