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Dysiherbols A-C and Dysideanone E, Cytotoxic and NF-κB Inhibitory Tetracyclic Meroterpenes from a Dysidea sp. Marine Sponge.
Four new tetracyclic meroterpnes, dysiherbols A-C (1-3) and dysideanone E (4), were isolated from a Dysidea sp. marine sponge collected from the South China Sea. Their complete structures and
Reniochalistatins A-E, cyclic peptides from the marine sponge Reniochalina stalagmitis.
The cyclic octapeptide reniochalistatin E showed biological activity in various cytotoxicity assays employing different tumor cell lines (RPMI-8226, MGC-803, HL-60, HepG2, and HeLa).
New Furan and Cyclopentenone Derivatives from the Sponge-Associated Fungus Hypocrea Koningii PF04
Two new furan derivatives, hypofurans A and B (1 and 2), and three new cyclopentenone derivatives, hypocrenones A–C (3–5), along with seven known compounds, were isolated from a marine fungus associated with the sponge Phakellia fusca, and compounds 10 and 11 were obtained for the first time as natural products.
Anti-inflammatory triterpenes from the leaves of Rosa laevigata.
Bioassay-guided fractionation of an EtOAc extract of the leaves of Rosa laevigata afforded two new 19-oxo-18,19-seco-ursane-type triterpenes and several of the isolated compounds exhibited moderate activities in anti-inflammatory assays in vitro.
Anti-inflammatory secondary metabolites from the leaves of Rosa laevigata.
Dysideanones A-C, unusual sesquiterpene quinones from the South China Sea sponge Dysidea avara.
Dysideanones A-C (1-3), three unusual sesquiterpene quinones with unprecedented carbon skeletons, were isolated from the South China Sea sponge Dysidea avara and showed cytotoxicity against two human cancer cell lines.
New diterpene alkaloids from the marine sponge Agelas mauritiana
Chemical investigation of an ethanol extract of the sponge Agelas mauritiana led to the isolation and characterization of five new diterpene alkaloids, namely, (−)-8′-oxo-agelasine B (1),
Formamido-Diterpenes from the South China Sea Sponge Acanthella cavernosa
Seven new formamido-diterpenes, cavernenes A–D, kalihinenes E and F, and kalihipyran C, together with five known compounds, were isolated from the South China Sea sponge Acanthella cavernosa and showed weak antifungal activity against fungi.
Dysidavarones A-D, new sesquiterpene quinones from the marine sponge Dysidea avara.
Four new sesquiterpene quinones possessing the unprecedented "dysidavarane" carbon skeleton were isolated from the South China Sea sponge Dysidea avara and their cytotoxic activity against four human cancer cell lines and PTP1B inhibitory activity were evaluated.