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Survivin expression and serum levels in pancreatic cancer
TLDR
Investigation of the expression and serum level of survivin in PDAC and its clinical significance as a prognostic factor found significant associations between survivin expression and perineural invasion, venous invasion, and lymph node status and a significant difference in overall survival was associated with Survivin expression. Expand
Combined effects of 17-DMAG and TNF on cells through a mechanism related to the NF-kappaB pathway
TLDR
It was found that combination of 17-DMAG and TNF treatments resulted in synergistic killing of malignant cells, which was confirmed by the apoptosis determination using a fluorescence microscopic assay following staining of the drug-treated cells with Hoescht 33258. Expand
Ropivacaine impairs mitochondrial biogenesis by reducing PGC-1α.
TLDR
Supporting evidence is provided that mitochondrial impairment is a key event in ropivacaine-mediated neurotoxicity, and the reduction of PGC-1α and its downstream signals are likely the molecular mechanism behind its cellular toxicity. Expand
Protective effects of dexmedetomidine on lung in rats with one-lung ventilation
TLDR
DEX can inhibit the production of inflammatory factors in the development and progression of pulmonary inflammation, which can inhibit lipid peroxidation, relieve pulmonary edema, and reduce lung injury after OLV, in order to protect the lung. Expand
Melanocortin 4 receptor antagonists attenuates morphine antinociceptive tolerance, astroglial activation and cytokines expression in the spinal cord of rat
TLDR
Repeated coadministration of HS014 and morphine, significantly prevented the development of morphine tolerance and a single administration of an MC4R antagonist restored morphine analgesic potency in morphine tolerant rats. Expand
Epigenetic modulation of Wnt signaling contributes to neuropathic pain in rats.
TLDR
The results suggest that the epigenetic upregulation of Wnt3a in the dorsal horn contributes to the maintenance of pain‑induced behavior in rats with CCI. Expand
Effect of edaravone on serum SP-A and arterial blood gas in patients with lobectomy.
TLDR
Edaravone can reduce serum SP-A levels in patients with lobectomy and alleviate acute lung injury to a certain extent in surgery. Expand
Grandinin down-regulates phosphorylation of epidermal growth factor receptor.
TLDR
Experimental results indicated grandinin significantly reduce malignant cell viability and effectively induces apoptosis of malignant lung cells by mediating phosphorylation down-regulation of cellular signaling proteins EGFR and AKT. Expand
Effect of Edaravone on Postoperative Cognitive Function and Cerebral Oxygen Metabolism in Elderly Patients with Spinal Surgery
TLDR
Edaravone can reduce the incidence of early postoperative cognitive dysfunction in elderly patients and the underlying mechanism may be related to improvement of cerebral oxygen metabolism. Expand
Cisatracurium inhibits the growth and induces apoptosis of ovarian cancer cells by promoting lincRNA-p21.
TLDR
Cisatracurium inhibited the progression of OVCAR-3 cells through upregulation of lincRNA-p21 expression activated by p53 inhibiting miR-181b expression, and the experimental results provide a new research idea for the application of cisatracURium in ovarian cancer. Expand