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Higher order energy functions have the ability to encode high level structural dependencies between pixels, which have been shown to be extremely powerful for image labeling problems. Their use, however, is severely hampered in practice by the intractable complexity of representing and minimizing such functions. We observed that higher order functions(More)
Dantrolene is the drug of choice for the treatment of malignant hyperthermia (MH) and is also useful for treatment of spasticity or muscle spasms associated with several clinical conditions. The current study examines the mechanisms of dantrolene's action on skeletal muscle and shows that one of dantrolene's mechanisms of action is to block(More)
BACKGROUND Polybutylcyanoacrylate (PBCA) nanoparticles coated with polysorbate-80 have been extensively proposed for delivering drugs into the animal brain and have shown great potential for therapeutic applications. In this study, we made an attempt to deliver the chemotherapeutic drug, temozolomide, into the brain by using PBCA nanoparticles. The(More)
Co-saliency detection aims at discovering the common salient objects existing in multiple images. Most existing methods combine multiple saliency cues based on fixed weights, and ignore the intrinsic relationship of these cues. In this paper, we provide a general saliency map fusion framework, which exploits the relationship of multiple saliency cues and(More)
Groups play an essential role in many social websites which promote users' interactions and accelerate the diffusion of information. Recommending groups that users are really interested to join is significant for both users and social media. While traditional group recommendation problem has been extensively studied, we focus on a new type of the problem,(More)
In the present work, we purified and characterized a novel toxin named hemicalcin from the venom of the Iranian chactoid scorpion Hemiscorpius lepturus where it represents 0.6% of the total protein content. It is a 33-mer basic peptide reticulated by three disulfide bridges, and that shares between 85 and 91% sequence identity with four other toxins, all(More)
What is happening around the world? When and where? Mining the geo-tagged Twitter stream makes it possible to answer the above questions in real-time. Although a single tweet can be short and noisy, proper aggregations of tweets can provide meaningful results. In this paper, we focus on hierarchical spatio-temporal hashtag clustering techniques. Our system(More)
Platelets are the second most abundant cell type in blood and are essential for maintaining haemostasis. Their count and volume are tightly controlled within narrow physiological ranges, but there is only limited understanding of the molecular processes controlling both traits. Here we carried out a high-powered meta-analysis of genome-wide association(More)
Ryanodine receptor type 1 (RyR1) produces spatially and temporally defined Ca2+ signals in several cell types. How signals received in the cytoplasmic domain are transmitted to the ion gate and how the channel gates are unknown. We used EGTA or neuroactive PCB 95 to stabilize the full closed or open states of RyR1. Single-channel measurements in the(More)
Bone marrow injury is a major adverse side effect of radiation and chemotherapy. Attempts to limit such damage are warranted, but their success requires a better understanding of how radiation and anticancer drugs harm the bone marrow. Here, we report one pivotal role of the BH3-only protein Puma in the radiosensitivity of hematopoietic stem cells (HSCs)(More)