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Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro.
The cardioprotection of astragaloside IV was accompanied by a significant increase in coronary flow both in vivo and in vitro, which suggest the potential roles of antioxidative and nitric oxide-inducing properties of aStragalus membranaceus in its protection from myocardial ischemia. Expand
Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia
The results presented here provide the first evidence of a neuroprotective effect of Astragaloside IV in the model of ischemic brain injury and suggest that the anti-infarction effect by Astranaceus may be derived at least in part from its antioxidant properties. Expand
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
This review discusses the recent advances in the understanding of STAT3, with a focus on STAT3’s oncogenic role in TNBC and proposes potential strategies that can be further examined for developing more specific and effective inhibitors for TNBC prevention and therapy. Expand
Iridoids and lignans from Valeriana jatamansi.
Thirteen new iridoids including seven iridolactones, jatamanins A-M (1-13), and a new lignan, (+)-9'-isovaleroxylariciresinol (14), together with seven known iridoids and 13 lignans were obtainedExpand
A metabonomic approach to the diagnosis of oral squamous cell carcinoma, oral lichen planus and oral leukoplakia.
The metabonomic approach based on the integral investigation of oral metabolites enables the detection of OSCC and precancerous lesions on noninvasive saliva samples and can be developed as a promising method for population-based screening of cancers and precancers in the oral cavity. Expand
Abiesatrines A-J: anti-inflammatory and antitumor triterpenoids from Abies georgei Orr.
Preliminary structure-activity relationship (SAR) investigations defined structural feature of the 24Z-olefinic bond key to the lanostane and cycloartane pharmacophore, and its biopathway was tentatively proposed. Expand
Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling.
The intrinsic association of ROS and IL-6/STAT3 signaling in human prostate carcinogenesis shed new light on this relationship and define therapeutic targets in this setting and established human prostate tumor-initiating cells based on physiologic adaption for the first time. Expand
Metabolomic analysis of thermally injured and/or septic rats.
Nine characteristic metabolites, including hypoxanthine, indoxyl sufate, glucuronic acid, gluconic acid, proline, uracil, nitrotyrosine, uric Acid, and trihydroxy cholanoic acid were identified in models of thermal injury and/or sepsis. Expand
Chemical Constituents of Plants from the Genus Dracocephalum
Computed tomography and magnetic resonance imaging findings of peripheral primitive neuroectodermal tumors of the head and neck.
The imaging features of pPNET of the head and neck are non-specific and should be included in the differential diagnosis of children and adolescents' regional tumors. Expand