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Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia
Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro.
- Wei-Dong Zhang, Hong Chen, Chuan Zhang, Run-hui Liu, Huiliang Li, Hong-Zhuan Chen
- Biology, ChemistryPlanta medica
The cardioprotection of astragaloside IV was accompanied by a significant increase in coronary flow both in vivo and in vitro, which suggest the potential roles of antioxidative and nitric oxide-inducing properties of aStragalus membranaceus in its protection from myocardial ischemia.
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
- Jiangjiang Qin, Li Yan, Jia Zhang, Wei-Dong Zhang
- Biology, ChemistryJournal of experimental & clinical cancer…
- 14 May 2019
This review discusses the recent advances in the understanding of STAT3, with a focus on STAT3’s oncogenic role in TNBC and proposes potential strategies that can be further examined for developing more specific and effective inhibitors for TNBC prevention and therapy.
Chemical Constituents of Plants from the Genus Dracocephalum
NFAT as cancer target: mission possible?
Abiesatrines A-J: anti-inflammatory and antitumor triterpenoids from Abies georgei Orr.
Preliminary structure-activity relationship (SAR) investigations defined structural feature of the 24Z-olefinic bond key to the lanostane and cycloartane pharmacophore, and its biopathway was tentatively proposed.
Metabolomic analysis of thermally injured and/or septic rats.
Computed tomography and magnetic resonance imaging findings of peripheral primitive neuroectodermal tumors of the head and neck.
Acylated iridoids with cytotoxicity from Valeriana jatamansi.
Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi and tested for their cytotoxicity against lung adenocarcinoma, metastatic prostate cancer, colon cancer, and hepatoma cell lines.
Inula sesquiterpenoids: structural diversity, cytotoxicity and anti-tumor activity
- Guo-Wei Wang, Jiangjiang Qin, Wei-Dong Zhang
- ChemistryExpert opinion on investigational drugs
- 12 February 2014
This article systematically reviews sesquiterpenoids isolated from the genus Inula that have appeared in literature up to August 2013, critically highlighting their anti-tumoral activities and relevant mechanistic insights.