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Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro.
- Wei-Dong Zhang, Hong Chen, Chuan Zhang, Run-hui Liu, Huiliang Li, Hong‐zhuan Chen
- Planta medica
The cardioprotection of astragaloside IV was accompanied by a significant increase in coronary flow both in vivo and in vitro, which suggest the potential roles of antioxidative and nitric oxide-inducing properties of aStragalus membranaceus in its protection from myocardial ischemia. Expand
Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia
The results presented here provide the first evidence of a neuroprotective effect of Astragaloside IV in the model of ischemic brain injury and suggest that the anti-infarction effect by Astranaceus may be derived at least in part from its antioxidant properties. Expand
STAT3 as a potential therapeutic target in triple negative breast cancer: a systematic review
- Jiang-Jiang Qin, Li Yan, Jia Zhang, Wei-Dong Zhang
- Journal of experimental & clinical cancer…
- 14 May 2019
This review discusses the recent advances in the understanding of STAT3, with a focus on STAT3’s oncogenic role in TNBC and proposes potential strategies that can be further examined for developing more specific and effective inhibitors for TNBC prevention and therapy. Expand
Iridoids and lignans from Valeriana jatamansi.
Thirteen new iridoids including seven iridolactones, jatamanins A-M (1-13), and a new lignan, (+)-9'-isovaleroxylariciresinol (14), together with seven known iridoids and 13 lignans were obtained… Expand
A metabonomic approach to the diagnosis of oral squamous cell carcinoma, oral lichen planus and oral leukoplakia.
- Shi-kai Yan, Ben-juan Wei, Zhong-ying Lin, Yun Yang, Zeng-tong Zhou, Wei-Dong Zhang
- Oral oncology
- 1 May 2008
The metabonomic approach based on the integral investigation of oral metabolites enables the detection of OSCC and precancerous lesions on noninvasive saliva samples and can be developed as a promising method for population-based screening of cancers and precancers in the oral cavity. Expand
Abiesatrines A-J: anti-inflammatory and antitumor triterpenoids from Abies georgei Orr.
- Xian-Wen Yang, Su-mei Li, +8 authors Wei-Dong Zhang
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 19 May 2010
Preliminary structure-activity relationship (SAR) investigations defined structural feature of the 24Z-olefinic bond key to the lanostane and cycloartane pharmacophore, and its biopathway was tentatively proposed. Expand
Generation of prostate tumor-initiating cells is associated with elevation of reactive oxygen species and IL-6/STAT3 signaling.
The intrinsic association of ROS and IL-6/STAT3 signaling in human prostate carcinogenesis shed new light on this relationship and define therapeutic targets in this setting and established human prostate tumor-initiating cells based on physiologic adaption for the first time. Expand
Metabolomic analysis of thermally injured and/or septic rats.
- Xin-ru Liu, Xing-feng Zheng, +4 authors Wei-Dong Zhang
- Burns : journal of the International Society for…
- 1 November 2010
Nine characteristic metabolites, including hypoxanthine, indoxyl sufate, glucuronic acid, gluconic acid, proline, uracil, nitrotyrosine, uric Acid, and trihydroxy cholanoic acid were identified in models of thermal injury and/or sepsis. Expand
Chemical Constituents of Plants from the Genus Dracocephalum
Computed tomography and magnetic resonance imaging findings of peripheral primitive neuroectodermal tumors of the head and neck.
- Wei-Dong Zhang, Yan-feng Chen, Chuan-xing Li, Liang Zhang, Zhi-bin Xu, Fu-jun Zhang
- European journal of radiology
- 1 November 2011
The imaging features of pPNET of the head and neck are non-specific and should be included in the differential diagnosis of children and adolescents' regional tumors. Expand