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With rapid advances in e-business and mobile technology, the personalized recommendation of mobile tourism becomes a critical issue for both researchers and practitioners. The big data, problems of new users and similar recommendations remain barriers for mobile tourism. Through a large dataset gathered by questionnaires, this paper develops a novel(More)
Two multisensor multiobservation detection schemes are analyzed and compared, and their hardware complexity (= number of sensors) is discussed. The studied schemes are: a Bayesian optimal parallel-sensor centralized architecture and a suboptimal binary distributed-detection system. Both systems are to have the same performance, as measured in terms of a(More)
Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for(More)
PURPOSE A four-generation Chinese family with 13 members affected with autosomal dominant congenital posterior polar cataract was studied. The purpose of this study was to identify the disease-causing gene in the family and to validate that mutations in CRYAB, the alphaB-crystallin gene, cause the congenital cataract. METHODS Linkage analysis was(More)
Motivated by the importance of infectious disease informatics (IDI) and the challenges to IDI system development and data sharing, we design and implement BioPortal, a Web-based IDI system that integrates cross-jurisdictional data to support information sharing, analysis, and visualization in public health. In this paper, we discuss general challenges in(More)
BACKGROUND Hereditary defects of tooth dentin are classified into two main groups: dentin dysplasia (DD) (types I and II) and dentinogenesis imperfecta (DGI) (types I, II, and III). Type II DGI is one of the most common tooth defects with an autosomal dominant mode of inheritance. One disease-causing gene, the dentin sialophosphoprotein (DSPP) gene, has(More)