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HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration
What drives the gradual degeneration of dopamine neurons in Parkinson's disease (PD), the second most common neurodegenerative disease, remains elusive. Here, we demonstrated, for the first time,Expand
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Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other, Driving Chronic Progression of Neurodegeneration in a Mouse Model of Parkinson’s Disease
Background Mechanisms whereby gene–environment interactions mediate chronic, progressive neurodegenerative processes in Parkinson’s disease (PD)—the second most common neurodegenerativeExpand
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Supplemental Material Neuroinflammation and α-Synuclein Dysfunction Potentiate Each Other Driving Chronic Progression of Parkinson ’ s Disease
Immunostaining and double-label immunofluorescence were performed as described previously using the following primary antibodies: SYN211 (1:500; Millipore), nSYN514 (1:150; Santa Cruz), andExpand