Wayne V. Moore

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Over the last 30 years glucose intolerance has been reported in a significant percentage of patients with amyotrophic lateral sclerosis (ALS). Currently, a controversy exists in determining whether the carbohydrate abnormality is disease-specific or secondary to decreased glucose utilization due to muscle atrophy. A reduction in glucose receptor space had(More)
BACKGROUND P53 expression and increased MIB-1 proliferation index have been shown to correlate with invasive behavior in pituitary adenomas. The purpose of this study was to determine whether these indices could be used to predict a higher likelihood of recurrence in clinically nonfunctional pituitary adenomas and thus guide adjuvant therapy. METHODS(More)
Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the mammalian NAD+ biosynthesis of a salvage pathway and exists in 2 known forms, intracellular Nampt (iNampt) and a secreted form, extracellular Nampt (eNampt). eNampt can generate an intermediate product, nicotinamide mononucleotide (NMN), which has been reported to support(More)
The adenylate cyclase activity in both hypophysectomized (hypox) and normal rat liver plasma membrane (RLM) has been characterized and compared in an attempt to decipher the molecular differences of the adenylate cyclase in these two membrane systems. Basal and glucagon- and fluoride-stimulated adenylate cyclase activities were severalfold greater in hypox(More)
AIMS/HYPOTHESIS Type 1 diabetes results from T cell mediated destruction of beta cells. We conducted a trial of antithymocyte globulin (ATG) in new-onset type 1 diabetes (the Study of Thymoglobulin to ARrest T1D [START] trial). Our goal was to evaluate the longer-term safety and efficacy of ATG in preserving islet function at 2 years. METHODS A(More)
This article presents five communication system options for single-aperture multiple-link (SAML) mission support that are capable of supporting a multiplicity of spacecraft that are simultaneously within the beamwidth of a single ground-station antenna. These proposed system options provide both short-term and long-term solutions for future deep-space(More)
Acknowledgements This paper has been abridged from of the original doctoral dissertation proposal, with highly technical parts removed. It has been specifically prepared for presentation at The title as listed in the conference program is A Ten Year Empirical Study of Property Tax Inequity by Assessment Capping. It is still a work-in-process, not yet a(More)
The relationship between social work field education, religiously affiliated organizations, and local philanthropic organizations is explored in this case study of a grant-funded project called the Congregational Social Work Education Initiative. Religiously affiliated organizations have traditionally been involved in the provision of social welfare(More)
CONTEXT Somavaratan (VRS-317) is a long-acting form of recombinant human GH under development for children and adults with GH deficiency (GHD). OBJECTIVES To determine the optimal somavaratan dose regimen to normalize IGF-1 in pediatric GHD and to evaluate safety and efficacy of somavaratan over 6 months. DESIGN Open-label, multicenter, single ascending(More)
The binding of [125I]bGH and [125I]hGH to bovine liver membranes is compared to characterize the somatotrophic hormone-receptor interaction. [125I]bGH binding exhibits higher nonspecific binding than [125I]hGH while the time-course of binding and displacement with unlabeled GH are similar. Divalent and monovalent cations enhance [125I]hGH binding with(More)