Wayne V. Moore

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Over the last 30 years glucose intolerance has been reported in a significant percentage of patients with amyotrophic lateral sclerosis (ALS). Currently, a controversy exists in determining whether the carbohydrate abnormality is disease-specific or secondary to decreased glucose utilization due to muscle atrophy. A reduction in glucose receptor space had(More)
Nicotinamide phosphoribosyltransferase (Nampt) is a rate-limiting enzyme in the mammalian NAD+ biosynthesis of a salvage pathway and exists in 2 known forms, intracellular Nampt (iNampt) and a secreted form, extracellular Nampt (eNampt). eNampt can generate an intermediate product, nicotinamide mononucleotide (NMN), which has been reported to support(More)
The adenylate cyclase activity in both hypophysectomized (hypox) and normal rat liver plasma membrane (RLM) has been characterized and compared in an attempt to decipher the molecular differences of the adenylate cyclase in these two membrane systems. Basal and glucagon- and fluoride-stimulated adenylate cyclase activities were severalfold greater in hypox(More)
AIMS/HYPOTHESIS Type 1 diabetes results from T cell mediated destruction of beta cells. We conducted a trial of antithymocyte globulin (ATG) in new-onset type 1 diabetes (the Study of Thymoglobulin to ARrest T1D [START] trial). Our goal was to evaluate the longer-term safety and efficacy of ATG in preserving islet function at 2 years. METHODS A(More)
This article presents five communication system options for single-aperture multiple-link (SAML) mission support that are capable of supporting a multiplicity of spacecraft that are simultaneously within the beamwidth of a single ground-station antenna. These proposed system options provide both short-term and long-term solutions for future deep-space(More)
CONTEXT Somavaratan (VRS-317) is a long-acting form of recombinant human GH under development for children and adults with GH deficiency (GHD). OBJECTIVES To determine the optimal somavaratan dose regimen to normalize IGF-1 in pediatric GHD and to evaluate safety and efficacy of somavaratan over 6 months. DESIGN Open-label, multicenter, single ascending(More)
The binding of 125I-labeled oGH, rGH and hGH to homologous liver membranes is compared to define the characteristics of somatotropic hormone-receptor interactions. The effect of pH and cations and the time-course of binding of these different GHs was similar when binding was determined in liver membranes from the homologous species. The time-course of(More)
The binding of [125I]bGH and [125I]hGH to bovine liver membranes is compared to characterize the somatotrophic hormone-receptor interaction. [125I]bGH binding exhibits higher nonspecific binding than [125I]hGH while the time-course of binding and displacement with unlabeled GH are similar. Divalent and monovalent cations enhance [125I]hGH binding with(More)
Only 2 of 6 patients with myotonic dystrophy had glucose intolerance and hyperinsulinemia. All, however, had markedly reduced insulin binding to specific receptors on circulating monocytes. A significant difference in receptor affinity for insulin was observed, but the difference in affinity was not as marked as that in the amount of 125I-insulin bound per(More)
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