Wayne R. Sampson

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A comparative study has been undertaken between Hmb-protected amino acid and pseudoproline building block analogues for use in the solid phase synthesis of 'difficult' peptides. Both of these derivatives act by blocking inter- and intramolecular hydrogen bonding, which has been shown to be a major cause of poor synthesis/quality/efficiency. While the two(More)
The synthesis of peptide and small molecule hydroxamic acids utilising SynPhase™ crowns is demonstrated. A hydroxylamine trityl linker is generated from chlorotrityl derivatised Synphase™ crowns by reaction with N-hydroxyphthalimide followed by subsequent deprotection. The loading of hydroxylamine crowns is quantified spectrophotometrically by measuring(More)
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