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Fine Mapping of Genetic Variants in BIN1, CLU, CR1 and PICALM for Association with Cerebrospinal Fluid Biomarkers for Alzheimer's Disease
Recent genome-wide association studies of Alzheimer's disease (AD) have identified variants in BIN1, CLU, CR1 and PICALM that show replicable association with risk for disease. We have thoroughly… Expand
Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels.
- John S. K. Kauwe, Carlos Cruchaga, +7 authors A. Goate
- Biology, Medicine
- Journal of Alzheimer's disease : JAD
Recent large-scale genetic studies of late-onset Alzheimer's disease have identified risk variants in CALHM1, GAB2, and SORL1. The mechanisms by which these genes might modulate risk are not… Expand