Wayne E. Berryhill

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The Kresge Hearing Research Institute-3 (KHRI-3) antibody binds to a guinea pig inner ear supporting cell antigen (IESCA) and causes hearing loss. To gain insight into the mechanism of antibody-induced hearing loss, we used antibody immunoaffinity purification to isolate the IESCA, which was then sequenced by mass spectroscopy, revealing 10 guinea pig(More)
OBJECTIVE To discuss the current management options for giant-cell tumors (GCTs) involving the temporal bone and present two case reports and a review of the literature. METHOD In a tertiary-care academic medical center, two patients with GCTs of the temporal bone were evaluated and managed. The patients underwent gross total resection and curettage of(More)
The use of intratympanic gentamicin is currently a popular and easily performed office procedure for the conservative treatment of the Meniere's disease patient who has failed medical therapy or who is not a candidate for surgical therapy. The procedure provides excellent control for the symptom of vertigo. Despite this success, there remains a significant(More)
BACKGROUND The use of intratympanic (IT) steroids for the treatment of inner ear disorders is promising, but the clinical challenges of prolonged middle ear drug application have proven burdensome, and a sustainable delivery system is yet to be developed. METHOD In this study, a guinea pig model was used to determine if dexamethasone in combination with a(More)
OBJECTIVE To determine whether unilateral or bilateral cochlear implantation affects the functional balance of children when compared with children with severe-to-profound bilateral hearing loss without a cochlear implant. DESIGNS An observational case control study. METHODS Three cohorts of children aged 4 to 17 years were studied: those with(More)
INTRODUCTION Antibiotic resistance has complicated the management of the draining ear. In this study, we examine the factors predisposing to resistance, as well as the role culture played in the management of these patients. MATERIALS AND METHODS A retrospective chart review was performed on all patients with a complaint of otorrhea during a 3-year(More)
The advantages of rigid fixation in adult craniofacial surgery are well documented, and implanted hardware is not routinely removed unless specifically indicated. There is a tendency, however, to remove hardware in children because of concerns with growth restriction, plate migration, and the lack of information on the fate of miniplates when used in(More)
OBJECTIVE To review our experience with laser myringoplasty using a potassium-titanyl-phosphate (KTP) laser for pars tensa atelectasis. STUDY DESIGN Retrospective review. METHODS A pulsed diode KTP laser (532 nm) was used to tighten the tympanic membrane after lysis of middle ear adhesions through a myringotomy. A tympanostomy tube was then placed.(More)
Antibodies to neural antigens cause several neurological diseases, myasthenia gravis with its acetylcholine receptor antibodies being perhaps the best known. Autoimmune damage is also suspected as a cause of rapidly progressive hearing loss. In this issue, Nair et al. track down the antigen underlying hearing loss that is caused by an antibody (KHRI-3)(More)