Wayne E. Berryhill

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The Kresge Hearing Research Institute-3 (KHRI-3) antibody binds to a guinea pig inner ear supporting cell antigen (IESCA) and causes hearing loss. To gain insight into the mechanism of antibody-induced hearing loss, we used antibody immunoaffinity purification to isolate the IESCA, which was then sequenced by mass spectroscopy, revealing 10 guinea pig(More)
BACKGROUND The use of intratympanic (IT) steroids for the treatment of inner ear disorders is promising, but the clinical challenges of prolonged middle ear drug application have proven burdensome, and a sustainable delivery system is yet to be developed. METHOD In this study, a guinea pig model was used to determine if dexamethasone in combination with a(More)
OBJECTIVE To determine whether unilateral or bilateral cochlear implantation affects the functional balance of children when compared with children with severe-to-profound bilateral hearing loss without a cochlear implant. DESIGNS An observational case control study. METHODS Three cohorts of children aged 4 to 17 years were studied: those with(More)
INTRODUCTION Antibiotic resistance has complicated the management of the draining ear. In this study, we examine the factors predisposing to resistance, as well as the role culture played in the management of these patients. MATERIALS AND METHODS A retrospective chart review was performed on all patients with a complaint of otorrhea during a 3-year(More)
Antibodies to neural antigens cause several neurological diseases, myasthenia gravis with its acetylcholine receptor anti-bodies being perhaps the best known. Au-toimmune damage is also suspected as a cause of rapidly progressive hearing loss. In this issue, Nair et al. track down the antigen underlying hearing loss that is caused by an antibody (KHRI-3)(More)
HYPOTHESIS The goal of this study was to map the VIIIth cranial nerve by electrical stimulation. Specifically, the authors sought to 1) characterize auditory and vestibular evoked responses elicited by electrical stimuli delivered directly to the exposed surface of the VIIIth cranial nerve and 2) compare electrically evoked responses elicited in brainstem(More)
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