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INTRODUCTION: Goitrogenesis is thought to be due to hyperstimulation of the thyroid stimulating hormone (TSH) receptor and is associated with dramatic andiogenesis within the thyroid. The angiogenic growth factors, fibroblast growth factor (FGF-2) and its receptor (FGFR-1) as well as Tie-2 (the receptor for the angiopoietins) are elevated in both the human(More)
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