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Effects of Ghrelin Administration on Left Ventricular Function, Exercise Capacity, and Muscle Wasting in Patients With Chronic Heart Failure
TLDR
The effects of ghrelin on left ventricular (LV) function, exercise capacity, and muscle wasting in patients with chronic heart failure (CHF), and a significant decrease in plasma norepinephrine are investigated. Expand
Characteristics and Distribution of M Cells in Arterially Perfused Canine Left Ventricular Wedge Preparations
TLDR
This study uses an arterially perfused wedge preparation to examine the characteristics and distribution of M cells within the anterior wall of the canine left ventricle under more physiological conditions. Expand
Sodium Channel Block With Mexiletine Is Effective in Reducing Dispersion of Repolarization and Preventing Torsade de Pointes in LQT2 and LQT3 Models of the Long-QT Syndrome
Background This study examines the contribution of transmural heterogeneity of transmembrane activity to phenotypic T-wave patterns and the effects of pacing and of sodium channel block underExpand
Chronic Administration of Ghrelin Improves Left Ventricular Dysfunction and Attenuates Development of Cardiac Cachexia in Rats With Heart Failure
TLDR
This work investigated whether ghrelin improves left ventricular (LV) dysfunction and attenuates cardiac cachexia in rats with chronic heart failure (CHF) and showed a significantly greater increase in body weight than those given placebo. Expand
Cellular Basis for the ECG Features of the LQT1 Form of the Long-QT Syndrome
Background—This study examines the cellular basis for the phenotypic appearance of broad-based T waves, increased transmural dispersion of repolarization (TDR), and torsade de pointes (TdP) inducedExpand
Localization of Optimal Ablation Site of Idiopathic Ventricular Tachycardia from Right and Left Ventricular Outflow Tract by Body Surface ECG
TLDR
Body surface maps and 12-lead ECGs were investigated in 35 VTs from the RVOT and 5 VTs with the origin confirmed during the ablation procedure, finding the location of the minimum at the early-to-mid QRS. Expand
Cellular and Ionic Basis for T-Wave Alternans Under Long-QT Conditions
TLDR
This study examines the cellular and ionic basis for TWA induced by rapid pacing under conditions mimicking the LQT3 form of the congenital LQTS in an arterially perfused canine left ventricular wedge preparation. Expand
Elevated Circulating Level of Ghrelin in Cachexia Associated With Chronic Heart Failure
TLDR
Investigating the pathophysiology of ghrelin in the cachexia associated with chronic heart failure found it to be a novel growth hormone-releasing peptide, isolated from the stomach, that may also cause a positive energy balance by stimulating food intake and inducing adiposity. Expand
Exercise Stress Test Amplifies Genotype-Phenotype Correlation in the LQT1 and LQT2 Forms of the Long-QT Syndrome
TLDR
This data indicates that the interval between peak and end of T wave (Tpe) in transmural ECGs reflects transmural dispersion of repolarization (TDR), which is amplified by β-adrenergic stimulation in the LQT1 model. Expand
Effects of a K+ Channel Opener to Reduce Transmural Dispersion of Repolarization and Prevent Torsade de Pointes in LQT1, LQT2, and LQT3 Models of the Long-QT Syndrome
Background—This study examines the effects of nicorandil, a K+ channel opener, on transmural dispersion of repolarization (TDR) and induction of torsade de pointes (TdP) under conditions mimickingExpand
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