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  • Takashi Kitaguchi, Yuta Moriyama, +17 authors Norimasa Miyamoto
  • Medicine
  • Journal of pharmacological and toxicological…
  • 2016 (First Publication: 1 March 2016)
  • INTRODUCTION Drug-induced QT prolongation is a major safety issue during drug development because it may lead to lethal ventricular arrhythmias. In this study, we evaluated the utility ofExpand
  • Ken-Ichi Fujita, Fumio Nagashima, +15 authors Yasutsuna Sasaki
  • Medicine, Biology
  • Biological & pharmaceutical bulletin
  • 2008
  • ATP-binding cassette, sub-family C, number 2 (ABCC2) is involved in the biliary excretion of irinotecan and its metabolites, SN-38 and SN-38 glucuronide. Effects of the ABCC2 genotype on theExpand
  • Kazuhiro Araki, Ken-Ichi Fujita, +7 authors Yasutsuna Sasaki
  • Biology, Medicine
  • Cancer science
  • 2006 (First Publication: 1 November 2006)
  • Pharmacogenetic testing for UDP-glucuronosyltransferase (UGT) 1A1*28, a promoter variant of the UGT1A1 gene, is now carried out clinically to estimate the risk of irinotecan-associated toxicity. WeExpand