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Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice.
It is demonstrated thatIRF8 regulates chromatin at the lymphoid-primed multipotent progenitor (LMPP) stage to induce early commitment toward DCs, and early expression of the key transcription factor IRF8 changes chromatin states in otherwise multipotential progenitors, biasing their fate decision towardDCs. Expand
Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.
The results illustrate the dynamic process by which key transcription factors regulate enhancer formation and, therefore, direct future gene expression to achieve mononuclear phagocyte development. Expand
Regulation of Mitophagy By O-Linked N-Acetylglucosamine Transferase Is Essential for Hematopoietic Stem Cell Maintenance
Hematopoietic stem cells (HSCs) reside in hypoxic niche in the bone marrow (BM), where they are maintained in quiescent state. To adapt to this hypoxic microenvironment, HSCs generate ATP mainly from… Expand
Angiotensin receptor-binding molecule in leukocytes in association with the systemic and leukocyte inflammatory profile.
It is suggested that leukocyte ATRAP is an emerging marker capable of reflecting the systemic and leukocytes inflammatory profile, and plays a role as an anti-inflammatory factor in the pathophysiology of NCDs. Expand
OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.
The results reveal that OGT critically regulates maintenance and stress response of HSCs by ensuring mitochondrial quality through PINK1-dependent mitophagy. Expand
A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes.
It is demonstrated that high, low or null expression of IRF8 in hematopoietic progenitor cells promotes differentiation toward type 1 conventional DCs, Ly6C+ monocytes or neutrophils, respectively, via epigenetic regulation of distinct sets of enhancers in cooperation with other transcription factors. Expand
Compromised anti-tumor–immune features of myeloid cell components in chronic myeloid leukemia patients
- Ibuki Harada, Haruka Sasaki, +16 authors Tomohiko Tamura
- Scientific reports
- 10 September 2021
Chronic myeloid leukemia (CML) is a form of myeloproliferative neoplasm caused by the oncogenic tyrosine kinase BCR-ABL. Although tyrosine kinase inhibitors have dramatically improved the prognosis… Expand
Metabolic Regulation of Hematopoietic Stem Cells by O-Linked N-Acetylglucosamine Transferase
THE TRANSCRIPTION FACTOR IRF8 EPIGENETICALLY REGULATES EARLY DENDRITIC CELL SPECIFICATION
It is demonstrated that IRF8 regulates chromatin at the LMPP stage to induce early commitment towardsDCs and changes chromatin states in otherwise multipotent progenitors, thereby biasing their fate decision towards DCs. Expand