Wataru Kagawa

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Crystal structure of the human centromeric nucleosome containing CENP-A.

Hiroaki Tachiwana, Wataru Kagawa, +9 authors Hitoshi Kurumizaka
Nature
2011

In eukaryotes, accurate chromosome segregation during mitosis and meiosis is coordinated by kinetochores, which are unique chromosomal sites for microtubule attachment. Centromeres specify the… (More)

Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form.

Wataru Kagawa, Hitoshi Kurumizaka, +4 authors Shigeyuki Yokoyama
Molecular cell
2002

The human Rad52 protein forms a heptameric ring that catalyzes homologous pairing. The N-terminal half of Rad52 is the catalytic domain for homologous pairing, and the ring formed by the domain… (More)

Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure

Gabriella Perez, Beth M. Acton, +18 authors Jonathan L. Tilly
Cell Death and Differentiation
2007

Although the identification of specific genes that regulate apoptosis has been a topic of intense study, little is known of the role that background genetic variance plays in modulating cell death.… (More)

Enhancing Survival of Mouse Oocytes Following Chemotherapy or Aging by Targeting Bax and Rad51

Loro L. Kujjo, T. Laine, +4 authors Gloria Ines Perez
PloS one
2010

BACKGROUND Therapeutic approaches to preserve fertility in females undergoing cancer treatments are currently ineffective. This is partly due to limited knowledge of the molecular mechanisms that… (More)

Structural polymorphism in the L1 loop regions of human H2A.Z.1 and H2A.Z.2

Naoki Horikoshi, Koichi Sato, +9 authors Hitoshi Kurumizaka
Acta crystallographica. Section D, Biological…
2013

The histone H2A.Z variant is widely conserved among eukaryotes. Two isoforms, H2A.Z.1 and H2A.Z.2, have been identified in vertebrates and may have distinct functions in cell growth and gene… (More)

Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair.

Koichi Sato, Masamichi Ishiai, +11 authors Hitoshi Kurumizaka
The EMBO journal
2012

Fanconi anaemia (FA) is a rare hereditary disorder characterized by genomic instability and cancer susceptibility. A key FA protein, FANCD2, is targeted to chromatin with its partner, FANCI, and… (More)

The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP DnaA-specific initiation complexes.

Kenji Keyamura, Norie Fujikawa, +7 authors Tsutomu Katayama
Genes & development
2007

Escherichia coli DiaA is a DnaA-binding protein that is required for the timely initiation of chromosomal replication during the cell cycle. In this study, we determined the crystal structure of DiaA… (More)

Structural basis for octameric ring formation and DNA interaction of the human homologous-pairing protein Dmc1.

Takashi Kinebuchi, Wataru Kagawa, +5 authors Shigeyuki Yokoyama
Molecular cell
2004

The human Dmc1 protein, a RecA/Rad51 homolog, is a meiosis-specific DNA recombinase that catalyzes homologous pairing. RecA and Rad51 form helical filaments, while Dmc1 forms an octameric ring. In… (More)

Human Rad51 amino acid residues required for Rad52 binding.

Hitoshi Kurumizaka, Hiroaki Aihara, Wataru Kagawa, T. Shibata, S. Yokoyama
Journal of molecular biology
1999

The Rad51 protein, a homologue of the bacterial RecA protein, is an essential factor for both meiotic and mitotic recombination. The N-terminal domain of the human Rad51 protein (HsRad51) directly… (More)

Homologous pairing promoted by the human Rad52 protein.

Wataru Kagawa, Hitoshi Kurumizaka, Shukuko Ikawa, S. Yokoyama, T. Shibata
The Journal of biological chemistry
2001

The Rad52 protein, which is unique to eukaryotes, plays important roles in the Rad51-dependent and the Rad51-independent pathways of DNA recombination. In the present study, we have biochemically… (More)

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