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Cimetidine antagonizes histamine's effects on some cancers and improves survival when given in the perioperative period.
Histamine has recently been shown to be a growth factor for some gastric and colorectal cancer cells. Previous studies have shown that cimetidine blocks in vitro and in vivo histamine-stimulated… (More)
BACKGROUND Cimetidine preserves postoperative immune function and inhibits the growth of some cancers. In this study, the effect of cimetidine on the local immune response to colorectal carcinoma… (More)