Wanqun Chen

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The clinical syndrome of thalassemia intermedia (TI) results from the β-globin genotypes in combination with factors to produce fetal haemoglobin (HbF) and/or co-inheritance of α-thalassemia. However, very little is currently known of the molecular basis of Chinese TI patients. We systematically analyzed and characterized β-globin genotypes, α-thalassemia(More)
AIMS Research related to type 2 diabetes mellitus (DM) and parameters of electrocardiography (ECG) was limited. Patients with and without DM (NDM) were randomly enrolled in a study to exploit the influence of DM on planar QRS and T vectors derived from the Virtual Holter process. METHODS A total of 216 (NDM) and 127 DM patients were consecutively and(More)
BACKGROUND This study was designed to identify the pathogenic mutation in a Chinese family with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) using whole genome sequencing (WGS). METHODS AND RESULTS Probands II:1 and II:2 underwent routine examinations for diagnosis. Genomic DNA was extracted from the peripheral blood of family(More)
In this paper an integrated dynamic design and modeling system is developed for aerostatic spindle development. This system integrates initial structural design, bearing stiffness computation and the spindle dynamic performance prediction. Modal fitting is used to transform the finite element model into a two-degree-of-freedom system model, which will make(More)
Digoxin is widely used to treat various heart conditions. In order to clarify the association between digoxin and anemia adverse reaction, we inspected case reports submitted to the FDA Adverse Event Reporting System (FAERS) between January 2004 and December 2015. These reports involved 75618 atrial fibrillation patients and 15699 heart failure patients.(More)
Non-alcoholic steatosis hepatitis (NASH) is one important step in the progression of non-alcoholic fatty liver disease (NAFLD), with the activation of hepatic stellate cells (HSCs) as its key mediator for liver fibrosis. Osteopontin (OPN) is closely related with fibrosis and is important for cell adhesion, migration, proliferation and rearrangement of(More)
Glucocorticoid treatment represents a standard palliative treatment for Duchenne muscular dystrophy (DMD) patients, but various adverse effects have limited this treatment. In an effort to understand the mechanism(s) by which glucocorticoids impart their effects on the dystrophic muscle, and potentially reduce the adverse effects, we have studied the effect(More)
In micro-milling, cutting forces generate non-negligible tool deflection, which has a significant influence on the machining process and on workpiece accuracy. This paper investigates the tool deflection during micro-milling and its effect on cutting force and surface generation. The distribution of cutting forces acting on the tool is calculated with a(More)
This paper presents an integrated system used for ultra precision machine tool (UPMT) design in conceptual and fundamental design stage. This system is based on the dynamics, thermodynamics and error budget theory. The candidate configurations of the machine tool are first selected from the configuration library or a novel configuration designed by the(More)
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